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PMID: 23420870 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Comment

Exosomes: looking back three decades and into the future.

The Journal of cell biology ·Vol. 200 ·No. 4 ·2013-02-18 ·Pages 367-71

Harding CV, Heuser JE, Stahl PD

Abstract

Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease, including intercellular communication. We discuss the initial experiments that led to the discovery of exosomes and highlight some of the exciting current directions in the field.

MeSH Terms
Cell Polarity/physiology Endocytosis/physiology Models, Biological Saccharomyces/cytology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Harding Clifford V
Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA.
Heuser John E
Stahl Philip D
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.201212113
Published
2013-02-18
Pages
367-71
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC3575527
Subset
IM
Corrections
ErratumIn
-
CommentOn
PMID: 23401000
External Links
PubMed source DOI: 10.1083/jcb.201212113 PMC Full Text View journal details
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