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PMID: 23238760 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

STING and the innate immune response to nucleic acids in the cytosol.

Nature immunology ·Vol. 14 ·No. 1 ·2013-01-00 ·Pages 19-26

Burdette DL, Vance RE

Abstract

Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic pathogens. Conversely, inappropriate responses to cytosolic nucleic acids can produce severe autoimmune pathology. The host protein STING has been identified as a central signaling molecule in the innate immune response to cytosolic nucleic acids. STING seems to be especially critical for responses to cytosolic DNA and the unique bacterial nucleic acids called 'cyclic dinucleotides'. Here we discuss advances in the understanding of STING and highlight the many unresolved issues in the field.

MeSH Terms
Animals Autoimmune Diseases/etiology,immunology Bacterial Infections/complications,immunology Cytosol/immunology DNA, Bacterial/immunology Host-Pathogen Interactions Humans Immunity, Innate Membrane Proteins/immunology Nucleotides, Cyclic/immunology Protein Transport/immunology Signal Transduction
Chemicals
DNA, Bacterial Membrane Proteins Nucleotides, Cyclic STING1 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Burdette Dara L
Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California, Berkeley, Berkeley, California, USA.
Vance Russell E
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.2491
Published
2013-01-00
Pages
19-26
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Grants
NIAID NIH HHS · AI063302 · United States
NIAID NIH HHS · AI075039 · United States
NIAID NIH HHS · AI082357 · United States
NIAID NIH HHS · AI091100 · United States
External Links
PubMed source DOI: 10.1038/ni.2491 View journal details
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