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PMID: 17063184 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Toll-like receptors in systemic autoimmune disease.

Nature reviews. Immunology ·Vol. 6 ·No. 11 ·2006-11-00 ·Pages 823-35

Marshak-Rothstein A

Abstract

Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vitro studies have documented activation of both autoreactive B cells and plasmacytoid dendritic cells by mammalian TLR ligands. The issue of whether these in vitro observations translate to an in vivo role for TLRs in either the initiation or the progression of systemic autoimmune disease is a subject of intense research; data are beginning to emerge showing that this is the case.

MeSH Terms
Animals Autoantibodies/biosynthesis,immunology Humans Interferon-alpha/immunology Ligands Lupus Erythematosus, Systemic/immunology,metabolism Models, Immunological Toll-Like Receptors/immunology,metabolism
Chemicals
Autoantibodies Interferon-alpha Ligands Toll-Like Receptors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Marshak-Rothstein Ann
Department of Microbiology, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA. amrothst@bu.edu
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1733
DOI
10.1038/nri1957
Email
amrothst@bu.edu
Published
2006-11-00
Pages
823-35
Language
English
Region
England
NLM ID
101124169
PMCID
PMC7097510
Subset
IM
External Links
PubMed source DOI: 10.1038/nri1957 PMC Full Text View journal details
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