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PMID: 2320579 Published · ppublish English Comparative Study Journal Article

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 7 ·1990-04-00 ·Pages 2628-32

Conn G, Bayne ML, Soderman DD, Kwok PW, Sullivan KA, Palisi TM, Hope DA, Thomas KA

Abstract

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA/genetics Endothelium, Vascular/metabolism Glycoproteins/genetics,isolation & purification Growth Substances/genetics,isolation & purification Humans Macromolecular Substances Molecular Sequence Data Oligonucleotide Probes Platelet-Derived Growth Factor/genetics Polymerase Chain Reaction Rats Sequence Homology, Nucleic Acid Vascular Endothelial Growth Factor A
Chemicals
Glycoproteins Growth Substances Macromolecular Substances Oligonucleotide Probes Platelet-Derived Growth Factor Vascular Endothelial Growth Factor A DNA
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Conn G
Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
Bayne M L
Soderman D D
Kwok P W
Sullivan K A
Palisi T M
Hope D A
Thomas K A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.7.2628
Published
1990-04-00
Pages
2628-32
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53743
Subset
IM
Databases
GENBANK
M32167
External Links
PubMed source DOI: 10.1073/pnas.87.7.2628 PMC Full Text View journal details
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