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PMID: 23139145 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Transfer RNA modifications: nature's combinatorial chemistry playground.

Wiley interdisciplinary reviews. RNA ·Vol. 4 ·No. 1 ·2013-00-00 ·Pages 35-48

Jackman JE, Alfonzo JD

Abstract

Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their differing effects. Recent developments in the modification field have highlighted the diversity of modifications in tRNA. From these, the combinatorial nature of modifications in explaining previously described phenotypes derived from their absence has emerged as a growing theme.

MeSH Terms
Humans Protein Biosynthesis/genetics,physiology RNA Processing, Post-Transcriptional RNA, Transfer/chemistry,genetics,metabolism Structure-Activity Relationship
Chemicals
RNA, Transfer
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jackman Jane E
The Ohio State Center for RNA Biology, The Ohio State University, Columbus, OH, USA. jackman.14@osu.edu
Alfonzo Juan D
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Article Info
Journal
Wiley interdisciplinary reviews. RNA
Abbr.
Wiley Interdiscip Rev RNA
ISSN
1757-7012
DOI
10.1002/wrna.1144
Email
jackman.14@osu.edu
Published
2013-00-00
Epub
2012-00-08
Pages
35-48
Language
English
Region
United States
NLM ID
101536955
PMCID
PMC3680101
Subset
IM
Grants
NIGMS NIH HHS · R01 GM084065 · United States
NIGMS NIH HHS · R01 GM087543 · United States
NIGMS NIH HHS · R01-GM087543 · United States
External Links
PubMed source DOI: 10.1002/wrna.1144 PMC Full Text View journal details
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