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PMID: 22952241 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The chromatin fingerprint of gene enhancer elements.

The Journal of biological chemistry ·Vol. 287 ·No. 37 ·2012-09-07 ·Pages 30888-96

Zentner GE, Scacheri PC

Abstract

Different cell types within a single organism are generally distinguished by strikingly different patterns of gene expression, which are dynamic throughout development and adult life. Distal enhancer elements are key drivers of spatiotemporal specificity in gene regulation. Often located tens of kilobases from their target promoters and functioning in an orientation-independent manner, the identification of bona fide enhancers has proved a formidable challenge. With the development of ChIP-seq, global cataloging of putative enhancers has become feasible. Here, we review the current understanding of the chromatin landscape at enhancers and how these chromatin features enable robust identification of tissue-specific enhancers.

MeSH Terms
Chromatin/genetics Chromosome Mapping/methods Enhancer Elements, Genetic/genetics Genome, Human/genetics Humans Organ Specificity
Chemicals
Chromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zentner Gabriel E
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Scacheri Peter C
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Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
1083-351X
DOI
10.1074/jbc.R111.296491
Published
2012-09-07
Epub
2012-00-05
Pages
30888-96
Language
English
Region
United States
NLM ID
2985121R
PMCID
PMC3438921
Subset
IM
Grants
NCI NIH HHS · R01 CA160356 · United States
NICHD NIH HHS · R01 HD056369 · United States
NHGRI NIH HHS · R01 HG004722 · United States
NHGRI NIH HHS · 5R01 HG004722 · United States
External Links
PubMed source DOI: 10.1074/jbc.R111.296491 PMC Full Text View journal details
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