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PMID: 22754556 Published · epublish English Journal Article

Multiple treg suppressive modules and their adaptability.

Frontiers in immunology ·Vol. 3 ·2012-00-00 ·Pages 178

Wing JB, Sakaguchi S

Abstract

Foxp3(+) regulatory T cells (Tregs) are a constitutively immunosuppressive cell type critical for the control of autoimmunity and inflammatory pathology. A range of mechanisms of Treg suppression have been identified and it has not always been clear how these different mechanisms interact in order to properly suppress autoimmunity and excessive inflammation. In recent years it has become clear that, while all Tregs seem to share some core suppressive mechanisms, they are also able to adapt to their surroundings in response to a variety of stimuli by homing to the sites of inflammation and exerting ancillary suppressive functions. In this review, we discuss the relevance and possible modes of Treg adaptability and put forward a modular model of Treg suppressive function. Understanding this flexibility may hold the key to understanding the full spectrum of Treg suppressive behavior.

Keywords
CTLA-4 Tregs adaptability suppression transcription factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wing James B
Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.
Sakaguchi Shimon
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Article Info
Journal
Frontiers in immunology
Abbr.
Front Immunol
ISSN
1664-3224
DOI
10.3389/fimmu.2012.00178
Published
2012-00-00
Epub
2012-00-29
Pages
178
Language
English
Region
Switzerland
NLM ID
101560960
PMCID
PMC3386489
External Links
PubMed source DOI: 10.3389/fimmu.2012.00178 PMC Full Text View journal details
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