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PMID: 22438251 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.

Blood ·Vol. 119 ·No. 19 ·2012-05-10 ·Pages 4430-40

Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ

Abstract

FOXP3+ regulatory T (Treg) cells are a broadly acting and potent anti-inflammatory population of CD4+ T cells essential for maintaining immune homeostasis and preventing debilitating autoimmunity. Based on chemokine receptor expression, we identified distinct populations of Treg cells in human blood expected to colocalize with different Th cell subsets. Although each population was functionally suppressive, they displayed unique patterns of pro- and anti-inflammatory cytokine production, differentially expressed lineage-specifying transcription factors, and responded differently to antigens associated with Th1 and Th17 responses. These results highlight a previously unappreciated degree of phenotypic and functional diversity in human Treg cells that allows subsets with unique specificities and immunomodulatory functions to be targeted to defined immune environments during different types of inflammatory responses.

MeSH Terms
Anti-Inflammatory Agents/metabolism CD4-Positive T-Lymphocytes/immunology,metabolism,physiology Cells, Cultured Cytokines/genetics,metabolism Forkhead Transcription Factors/genetics,metabolism Humans Inflammation Mediators/metabolism Phenotype T-Cell Antigen Receptor Specificity/genetics,immunology T-Lymphocytes, Helper-Inducer/immunology,metabolism,physiology T-Lymphocytes, Regulatory/classification,immunology,metabolism,physiology Transcription Factors/genetics,metabolism
Chemicals
Anti-Inflammatory Agents Cytokines FOXP3 protein, human Forkhead Transcription Factors Inflammation Mediators Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Duhen Thomas
Benaroya Research Institute, Seattle, WA 98101, USA.
Duhen Rebekka
Lanzavecchia Antonio
Sallusto Federica
Campbell Daniel J
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
1528-0020
DOI
10.1182/blood-2011-11-392324
Published
2012-05-10
Epub
2012-00-21
Pages
4430-40
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC3362361
Subset
IM
Grants
NIDDK NIH HHS · R01 DK072295 · United States
NIAMS NIH HHS · R01 AR055695 · United States
NIDDK NIH HHS · DK072295 · United States
NIAID NIH HHS · AI067750 · United States
NIAID NIH HHS · R56 AI067750 · United States
NIAMS NIH HHS · AR055695 · United States
NIAID NIH HHS · R01 AI067750 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1182/blood-2011-11-392324 PMC Full Text View journal details
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