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PMID: 19578369 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.

Nature immunology ·Vol. 10 ·No. 8 ·2009-08-00 ·Pages 857-63

Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F

Abstract

Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.

MeSH Terms
CD4-Positive T-Lymphocytes/cytology,immunology,metabolism Cell Differentiation Humans Immunologic Memory In Vitro Techniques Interleukin-17/biosynthesis Interleukins/biosynthesis Nuclear Receptor Subfamily 1, Group F, Member 3 Receptors, CCR10/metabolism Receptors, CCR4/metabolism Receptors, CCR6/metabolism Receptors, Retinoic Acid/metabolism Receptors, Thyroid Hormone/metabolism Skin/immunology T-Box Domain Proteins/metabolism T-Lymphocyte Subsets/cytology,immunology,metabolism T-Lymphocytes, Helper-Inducer/cytology,immunology,metabolism
Chemicals
CCR10 protein, human CCR4 protein, human CCR6 protein, human Interleukin-17 Interleukins Nuclear Receptor Subfamily 1, Group F, Member 3 RORC protein, human Receptors, CCR10 Receptors, CCR4 Receptors, CCR6 Receptors, Retinoic Acid Receptors, Thyroid Hormone T-Box Domain Proteins T-box transcription factor TBX21 interleukin-22
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Duhen Thomas
Institute for Research in Biomedicine, Bellinzona, Switzerland.
Geiger Rebekka
Jarrossay David
Lanzavecchia Antonio
Sallusto Federica
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.1767
Published
2009-08-00
Epub
2009-00-05
Pages
857-63
Language
English
Region
United States
NLM ID
100941354
Subset
IM
External Links
PubMed source DOI: 10.1038/ni.1767 View journal details
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