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PMID: 16533888 Published · ppublish English Comment Journal Article

In vivo sites and cellular mechanisms of T reg cell-mediated suppression.

The Journal of experimental medicine ·Vol. 203 ·No. 3 ·2006-03-20 ·Pages 489-92

Rudensky AY, Campbell DJ

Abstract

Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell-T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.

MeSH Terms
Animals Antigen Presentation/immunology Autoantigens/immunology CD4-Positive T-Lymphocytes/immunology Cell Adhesion/immunology Cell Communication/immunology Cell Movement/immunology Dendritic Cells/immunology Mice Mice, Transgenic Microscopy, Confocal/methods T-Lymphocytes, Regulatory/immunology
Chemicals
Autoantigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rudensky Alexander Y
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA. aruden@u.washington.edu
Campbell Daniel J
References (24)
24 references, click to expand
  1. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
    J Exp Med. 2005 Mar 7;201(5):737-46 PMID: 15753207
  2. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.
    J Immunol. 2005 Feb 15;174(4):1783-6 PMID: 15699103
  3. The role of self-peptides in the development of CD4+ CD25+ regulatory T cells.
    Curr Opin Immunol. 2005 Apr;17(2):131-6 PMID: 15766671
  4. Mechanisms of suppression by suppressor T cells.
    Nat Immunol. 2005 Apr;6(4):338-44 PMID: 15785759
  5. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.
    Nat Immunol. 2005 Apr;6(4):345-52 PMID: 15785760
  6. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection.
    J Immunol. 2005 May 1;174(9):5444-55 PMID: 15845457
  7. The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology.
    Curr Top Microbiol Immunol. 2005;293:25-42 PMID: 15981474
  8. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner.
    J Exp Med. 2005 Oct 17;202(8):1075-85 PMID: 16230475
  9. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
    J Exp Med. 2005 Nov 21;202(10):1387-97 PMID: 16301745
  10. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
    Nat Immunol. 2006 Jan;7(1):83-92 PMID: 16311599
  11. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.
    J Exp Med. 2006 Mar 20;203(3):505-11 PMID: 16533880
  12. Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens.
    J Exp Med. 2006 Mar 20;203(3):777-88 PMID: 16533885
  13. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.
    Nat Immunol. 2006 Apr;7(4):401-10 PMID: 16532000
  14. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
    Immunity. 2000 Apr;12(4):431-40 PMID: 10795741
  15. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
    J Exp Med. 2000 Jul 17;192(2):303-10 PMID: 10899917
  16. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.
    Nature. 2002 Dec 5;420(6915):502-7 PMID: 12466842
  17. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.
    Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10878-83 PMID: 12949259
  18. Control of T cell activation by CD4+CD25+ suppressor T cells.
    Novartis Found Symp. 2003;252:24-36; discussion 36-44, 106-14 PMID: 14609210
  19. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.
    Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10398-403 PMID: 15235129
  20. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.
    Immunity. 2004 Aug;21(2):267-77 PMID: 15308106
  21. Human T regulatory cells can use the perforin pathway to cause autologous target cell death.
    Immunity. 2004 Oct;21(4):589-601 PMID: 15485635
  22. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.
    J Exp Med. 1999 Oct 4;190(7):995-1004 PMID: 10510089
  23. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
    Eur J Immunol. 2004 Nov;34(11):2996-3005 PMID: 15468055
  24. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.
    Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):419-24 PMID: 15623559
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20060214
Email
aruden@u.washington.edu
Published
2006-03-20
Epub
2006-00-13
Pages
489-92
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2118229
Subset
IM
Corrections
CommentOn
PMID: 16533880
External Links
PubMed source DOI: 10.1084/jem.20060214 PMC Full Text View journal details
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