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PMID: 2272661 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily.

Immunogenetics ·Vol. 32 ·No. 6 ·1990-00-00 ·Pages 406-12

Wilson RK, Lai E, Kim LD, Hood L

Abstract

We describe the characterization of a novel subfamily of human T-cell receptor beta-chain variable TCRBV gene segments, detected through homology to a mouse Tcrb-V13 gene segment probe. The new human TCRBV gene segment subfamily TCRBV21 contains three members, all of which have been characterized with respect to nucleotide sequence, chromosomal location, and expression in human thymocytes and peripheral T lymphocytes. Our results indicate that one member of the TCRBV21 subfamily is not expressed in either tissue type although its coding region, promoter, recognition, and splice sequences all appear to be functional at the nucleotide level, possibly indicating regulation at the level of transcription.

MeSH Terms
Base Sequence Chromosome Mapping Cloning, Molecular Gene Expression Humans Molecular Sequence Data Receptors, Antigen, T-Cell/genetics
Chemicals
Receptors, Antigen, T-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wilson R K
Division of Biology, California Institute of Technology, Pasadena 91125.
Lai E
Kim L D
Hood L
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00241634
Published
1990-00-00
Pages
406-12
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Databases
GENBANK
M33233, M33234, M33235, M33236
External Links
PubMed source DOI: 10.1007/BF00241634 View journal details
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