Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.

Nature ·Vol. 308 ·No. 5955 ·1984-00-00 ·Pages 149-53

Hedrick SM, Cohen DI, Nielsen EA, Davis MM

Abstract

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes.

MeSH Terms

Animals B-Lymphocytes/immunology Cell Membrane/immunology Cloning, Molecular DNA/isolation & purification Genes Liver/immunology Mice Mice, Inbred Strains Nucleic Acid Hybridization Poly A/genetics Polyribosomes/metabolism RNA/genetics RNA, Messenger/genetics Receptors, Antigen, T-Cell/genetics T-Lymphocytes/immunology

Chemicals

RNA, Messenger Receptors, Antigen, T-Cell Poly A RNA DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hedrick S M

Cohen D I

Nielsen E A

Davis M M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/308149a0

Published

1984-00-00

Pages

149-53

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/308149a0 View journal details

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Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.

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