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PMID: 6208487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

Nature ·Vol. 312 ·No. 5989 ·1984-00-00 ·Pages 36-40

Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S

Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the alpha-subunit of the heterodimeric antigen receptor of this T-cell clone.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Line Clone Cells Cloning, Molecular DNA/analysis Genes Humans Immunoglobulins/genetics Macromolecular Substances Mice Poly A/genetics RNA/genetics RNA, Messenger Receptors, Antigen, T-Cell/genetics T-Lymphocytes, Cytotoxic/immunology Transcription, Genetic

Chemicals

Immunoglobulins Macromolecular Substances RNA, Messenger Receptors, Antigen, T-Cell Poly A RNA DNA

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Saito H

Kranz D M

Takagaki Y

Hayday A C

Eisen H N

Tonegawa S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/312036a0

Published

1984-00-00

Pages

36-40

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA-14051 · United States

NCI NIH HHS · CA-28900 · United States

NCI NIH HHS · CA-28900-04 · United States

Databases

GENBANK

X01134

External Links

PubMed source DOI: 10.1038/312036a0 View journal details

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A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

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