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PMID: 2269667 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Topologically restricted appearance in the developing chick retinotectal system of Bravo, a neural surface protein: experimental modulation by environmental cues.

The Journal of cell biology ·Vol. 111 ·No. 6 Pt 2 ·1990-12-00 ·Pages 3087-96

de la Rosa EJ, Kayyem JF, Roman JM, Stierhof YD, Dreyer WJ, Schwarz U

Abstract

A novel neural surface protein, Bravo, shows a pattern of topological restriction in the embryonic chick retinotectal system. Bravo is present on the developing optic fibers in the retina; however, retinal axons in the tectum do not display Bravo. The appearance of Bravo in vitro is modulated by environmental cues. Axons growing out from retinal explants on retinal basal lamina, their natural substrate, express Bravo, whereas such axons growing on collagen do not. Retinal explants provide a valuable system to characterize the mechanism of Bravo restriction, as well as the cellular signals controlling it. Bravo was identified with monoclonal antibodies from a collection generated against exposed molecules isolated by using a selective cell surface biotinylation procedure. The NH2-terminal sequence of Bravo shows similarity with L1, a neural surface molecule which is a member of the immunoglobulin superfamily. This possible relationship to L1, together with its restricted appearance, suggests an involvement of Bravo in axonal growth and guidance.

MeSH Terms
Amino Acid Sequence Animals Antibodies, Monoclonal Antigens, Surface/isolation & purification Avidin Axons/chemistry Biotin Chick Embryo/growth & development,metabolism Chromatography, Affinity Chromatography, High Pressure Liquid Immunohistochemistry Molecular Sequence Data Nerve Tissue Proteins/biosynthesis,chemistry,isolation & purification Optic Nerve/chemistry,embryology Retina/chemistry,embryology Superior Colliculi/chemistry,embryology
Chemicals
Antibodies, Monoclonal Antigens, Surface Bravo protein, Gallus gallus Nerve Tissue Proteins Avidin Biotin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
de la Rosa E J
Max-Planck-Institut für Enwicklungsbiologie, Abteilung Biochemie, Tübingen, Germany.
Kayyem J F
Roman J M
Stierhof Y D
Dreyer W J
Schwarz U
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.111.6.3087
Published
1990-12-00
Pages
3087-96
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2116392
Subset
IM
Grants
NEI NIH HHS · EY 07752 · United States
Corrections
ErratumIn
PMID: 1999455
External Links
PubMed source DOI: 10.1083/jcb.111.6.3087 PMC Full Text View journal details
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