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PMID: 3478724 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 21 ·1987-11-00 ·Pages 7753-7

Lagenaur C, Lemmon V

Abstract

The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.

MeSH Terms
Animals Antigens, Surface/isolation & purification,physiology Axons/physiology Cell Adhesion Cell Adhesion Molecules Cells, Cultured Cerebellum/cytology,physiology Chick Embryo Culture Media Membrane Proteins/isolation & purification,physiology Mice Molecular Weight Nerve Tissue Proteins/isolation & purification,physiology Neurons/cytology,physiology Superior Colliculi/cytology,physiology
Chemicals
Antigens, Surface Cell Adhesion Molecules Culture Media Membrane Proteins Nerve Tissue Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lagenaur C
Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh, PA 15261.
Lemmon V
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19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.21.7753
Published
1987-11-00
Pages
7753-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC299379
Subset
IM
Grants
NEI NIH HHS · R01 EY005285 · United States
PHS HHS · R01-5285 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.21.7753 PMC Full Text View journal details
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