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PMID: 22617421 Published · ppublish English Journal Article Review

Drugging Wnt signalling in cancer.

The EMBO journal ·Vol. 31 ·No. 12 ·2012-06-13 ·Pages 2737-46

Polakis P

Abstract

Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided.

MeSH Terms
Animals Gene Expression Regulation Humans Neoplasms/physiopathology Wnt Signaling Pathway
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Polakis Paul
Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA. ppolakis@gene.com
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.1038/emboj.2012.126
Email
ppolakis@gene.com
Published
2012-06-13
Epub
2012-00-22
Pages
2737-46
Language
English
Region
England
NLM ID
8208664
PMCID
PMC3380214
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1038/emboj.2012.126 PMC Full Text View journal details
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