The many ways of Wnt in cancer.

Current opinion in genetics & development ·Vol. 17 ·No. 1 ·2007-02-00 ·Pages 45-51

Polakis P

Abstract

More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of experiments originating with random proviral integration in mice. The significance of Wnt signaling in human cancer has since been buttressed by the identification of mutations in genes coding for the Wnt pathway components Axin, APC, and beta-catenin. This review summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their functional contribution to human tumor progression.

MeSH Terms

Axin Protein Genes, APC Glycogen Synthase Kinase 3/genetics Humans Intracellular Signaling Peptides and Proteins Models, Biological Mutation/genetics Neoplasms/genetics Proteins/genetics Repressor Proteins/genetics Signal Transduction/genetics TCF Transcription Factors/genetics Transcription Factor 7-Like 2 Protein Wnt Proteins/genetics beta Catenin/genetics

Chemicals

Axin Protein Intracellular Signaling Peptides and Proteins Proteins Repressor Proteins TCF Transcription Factors TCF7L2 protein, human Tcf7l2 protein, mouse Transcription Factor 7-Like 2 Protein WD repeat containing planar cell polarity effector Wnt Proteins beta Catenin Glycogen Synthase Kinase 3

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Polakis Paul

Department of Research, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ppolakis@gene.com

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/j.gde.2006.12.007

ppolakis@gene.com

Published

2007-02-00

Pages

45-51

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/j.gde.2006.12.007 View journal details

Analysis Services

The many ways of Wnt in cancer.

Contact

WeChat Official Account