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PMID: 22561834 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

T cell homing to epithelial barriers in allergic disease.

Nature medicine ·Vol. 18 ·No. 5 ·2012-05-04 ·Pages 705-15

Islam SA, Luster AD

Abstract

Allergic inflammation develops in tissues that have large epithelial surface areas that are exposed to the environment, such as the lung, skin and gut. In the steady state, antigen-experienced memory T cells patrol these peripheral tissues to facilitate swift immune responses against invading pathogens. In at least two allergy-prone organs, the skin and the gut, memory T cells are programmed during the initial antigen priming to express trafficking receptors that enable them to preferentially home to these organs. In this review we propose that tissue-specific memory and inflammation-specific T cell trafficking facilitates the development of allergic disease in these organs. We thus review recent advances in our understanding of tissue-specific T cell trafficking and how regulation of T cell trafficking by the chemokine system contributes to allergic inflammation in mouse models and in human allergic diseases of the skin, lung and gut. Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases.

MeSH Terms
Allergens/immunology Animals Asthma/immunology Cell Movement Chemokines/physiology Epithelium/immunology Food Hypersensitivity/immunology Humans Hypersensitivity/immunology Immunologic Memory Mice T-Lymphocytes/physiology Th2 Cells/physiology
Chemicals
Allergens Chemokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Islam Sabina A
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Luster Andrew D
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.2760
Published
2012-05-04
Epub
2012-00-04
Pages
705-15
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC3863331
Subset
IM
Grants
NIAID NIH HHS · R37 AI040618 · United States
NIAID NIH HHS · U19 AI095261 · United States
NIAID NIH HHS · U19AI095261 · United States
NIAID NIH HHS · R37AI040618 · United States
External Links
PubMed source DOI: 10.1038/nm.2760 PMC Full Text View journal details
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