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PMID: 22526416 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Ca2+-activated Cl- channels at a glance.

Journal of cell science ·Vol. 125 ·No. Pt 6 ·2012-03-15 ·Pages 1367-71

Berg J, Yang H, Jan LY

Abstract

暂无摘要

MeSH Terms
Alternative Splicing/genetics Animals Anoctamin-1 Calcium Signaling/genetics,physiology Chloride Channels/genetics,metabolism,physiology Humans Neoplasm Proteins/genetics,metabolism,physiology Predictive Value of Tests
Chemicals
ANO1 protein, human Anoctamin-1 Chloride Channels Neoplasm Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Berg Jim
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Yang Huanghe
Jan Lily Yeh
References (62)
62 references, click to expand
  1. A novel calcium-sensing domain in the BK channel.
    Biophys J. 1997 Sep;73(3):1355-63 PMID: 9284303
  2. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A.
    FASEB J. 2011 Mar;25(3):1058-68 PMID: 21115851
  3. ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.
    Br J Cancer. 2010 Aug 24;103(5):715-26 PMID: 20664600
  4. TMEM16A confers receptor-activated calcium-dependent chloride conductance.
    Nature. 2008 Oct 30;455(7217):1210-5 PMID: 18724360
  5. Chloride channels: often enigmatic, rarely predictable.
    Annu Rev Physiol. 2010;72:95-121 PMID: 19827947
  6. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles.
    J Physiol. 2009 Oct 15;587(Pt 20):4887-904 PMID: 19687122
  7. Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome.
    Blood. 2011 Apr 21;117(16):4399-400 PMID: 21511967
  8. Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.
    J Neurosci. 2009 Aug 12;29(32):10063-71 PMID: 19675239
  9. TMEM16B induces chloride currents activated by calcium in mammalian cells.
    Pflugers Arch. 2009 Oct;458(6):1023-38 PMID: 19475416
  10. Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies.
    Am J Hum Genet. 2010 Feb 12;86(2):213-21 PMID: 20096397
  11. A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle.
    J Gen Physiol. 2008 Jul;132(1):145-60 PMID: 18591421
  12. Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice.
    J Neurosci. 2000 Oct 15;20(20):7531-8 PMID: 11027211
  13. Interstitial cells of cajal as pacemakers in the gastrointestinal tract.
    Annu Rev Physiol. 2006;68:307-43 PMID: 16460275
  14. Expression and function of epithelial anoctamins.
    J Biol Chem. 2010 Mar 5;285(10):7838-45 PMID: 20056604
  15. New horizons in the treatment of cystic fibrosis.
    Br J Pharmacol. 2011 May;163(1):173-83 PMID: 21108631
  16. Calmodulin contributes to gating control in olfactory calcium-activated chloride channels.
    J Gen Physiol. 2006 Jun;127(6):737-48 PMID: 16735757
  17. The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels.
    J Clin Invest. 2010 Apr;120(4):1240-52 PMID: 20335661
  18. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.
    Proc Natl Acad Sci U S A. 2011 May 24;108(21):8891-6 PMID: 21555582
  19. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
    J Biol Chem. 2011 Jan 21;286(3):2365-74 PMID: 21084298
  20. The electrochemical basis of odor transduction in vertebrate olfactory cilia.
    Chem Senses. 2008 Nov;33(9):839-59 PMID: 18703537
  21. GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
    Physiol Rev. 2007 Oct;87(4):1215-84 PMID: 17928584
  22. Ca2+-activated Cl− currents are dispensable for olfaction.
    Nat Neurosci. 2011 Jun;14(6):763-9 PMID: 21516098
  23. A calcium-activated chloride current generates the after-depolarization of rat sensory neurones in culture.
    J Physiol. 1985 Jul;364:217-39 PMID: 2411915
  24. Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation.
    Neurogastroenterol Motil. 2011 Aug;23(8):760-5 PMID: 21585622
  25. Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.
    Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18168-72 PMID: 22006324
  26. TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells.
    J Physiol. 2010 Jul 1;588(Pt 13):2305-14 PMID: 20421283
  27. Regulation of fluid and electrolyte secretion in salivary gland acinar cells.
    Annu Rev Physiol. 2005;67:445-69 PMID: 15709965
  28. Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle.
    Am J Physiol. 1996 Aug;271(2 Pt 1):C435-54 PMID: 8769982
  29. Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.
    J Biol Chem. 2009 May 29;284(22):14875-80 PMID: 19363029
  30. Calcium-dependent chloride current induced by axotomy in rat sympathetic neurons.
    J Physiol. 1994 Mar 15;475(3):391-400 PMID: 8006824
  31. Calcium-dependent phospholipid scrambling by TMEM16F.
    Nature. 2010 Dec 9;468(7325):834-8 PMID: 21107324
  32. TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.
    J Biol Chem. 2009 Oct 16;284(42):28571-8 PMID: 19654323
  33. Initiation of the activation potential by an increase in intracellular calcium in eggs of the frog, Rana pipiens.
    Dev Biol. 1981 Jul 30;85(2):380-4 PMID: 6790319
  34. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
    FASEB J. 2011 Nov;25(11):4048-62 PMID: 21836025
  35. Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.
    J Biol Chem. 2010 Apr 23;285(17):12990-3001 PMID: 20177062
  36. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport.
    J Biol Chem. 2009 Oct 16;284(42):28698-703 PMID: 19679661
  37. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity.
    Science. 2008 Oct 24;322(5901):590-4 PMID: 18772398
  38. Expression profile and protein translation of TMEM16A in murine smooth muscle.
    Am J Physiol Cell Physiol. 2010 Nov;299(5):C948-59 PMID: 20686072
  39. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
    J Neurosci. 2009 May 27;29(21):6809-18 PMID: 19474308
  40. TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels.
    Mol Cell Proteomics. 2011 Feb;10(2):M110.004697 PMID: 20974900
  41. Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia.
    Am J Hum Genet. 2010 Dec 10;87(6):813-9 PMID: 21092923
  42. Studies on expression and function of the TMEM16A calcium-activated chloride channel.
    Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21413-8 PMID: 19965375
  43. Calcium-activated chloride channels in the retina.
    Channels (Austin). 2008 Jul-Aug;2(4):252-60 PMID: 18769137
  44. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity.
    Science. 1991 Jul 12;253(5016):202-5 PMID: 1712984
  45. The transmembrane protein TMEM16A is required for normal development of the murine trachea.
    Dev Biol. 2008 Sep 1;321(1):141-9 PMID: 18585372
  46. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.
    Am J Pathol. 2004 Jul;165(1):107-13 PMID: 15215166
  47. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents.
    Neuron. 1991 Apr;6(4):565-74 PMID: 2015092
  48. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
    Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3059-64 PMID: 14981236
  49. Regenerative component of slow waves in the guinea-pig gastric antrum involves a delayed increase in [Ca(2+)](i) and Cl(-) channels.
    J Physiol. 2002 May 1;540(Pt 3):907-19 PMID: 11986379
  50. Molecular components of signal amplification in olfactory sensory cilia.
    Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6052-7 PMID: 20231443
  51. Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A.
    J Biol Chem. 2011 Jan 14;286(2):1381-8 PMID: 21056985
  52. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.
    Cell. 2008 Sep 19;134(6):1019-29 PMID: 18805094
  53. Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse.
    J Neurophysiol. 2011 Jan;105(1):321-35 PMID: 21084687
  54. Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals.
    J Gen Physiol. 2000 Jan;115(1):59-80 PMID: 10613919
  55. Mechanism of calcium gating in small-conductance calcium-activated potassium channels.
    Nature. 1998 Oct 1;395(6701):503-7 PMID: 9774106
  56. Regulation of TMEM16A chloride channel properties by alternative splicing.
    J Biol Chem. 2009 Nov 27;284(48):33360-8 PMID: 19819874
  57. Calcium-activated chloride channels.
    Annu Rev Physiol. 2005;67:719-58 PMID: 15709976
  58. Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons.
    J Neurophysiol. 2003 Dec;90(6):3764-73 PMID: 12944538
  59. Electrical signals and their physiological significance in plants.
    Plant Cell Environ. 2007 Mar;30(3):249-257 PMID: 17263772
  60. The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).
    Am J Hum Genet. 2004 Jun;74(6):1255-61 PMID: 15124103
  61. Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina.
    J Physiol. 1982 Oct;331:253-84 PMID: 7153904
  62. A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity.
    J Physiol. 2009 Oct 15;587(Pt 20):4905-18 PMID: 19703958
Article Info
Journal
Journal of cell science
Abbr.
J Cell Sci
ISSN
1477-9137
Published
2012-03-15
Pages
1367-71
Language
English
Region
England
NLM ID
0052457
PMCID
PMC3336373
Subset
IM
Grants
NINDS NIH HHS · F32 NS066616 · United States
NINDS NIH HHS · R01 NS069229 · United States
NINDS NIH HHS · NS069229 · United States
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