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PMID: 225033 Published · ppublish English Journal Article Review

Infundibular neurons of the human hypothalamus simultaneously reactive with antisera against endorphins, ACTH, MSH and beta-LPH.

Cell and tissue research ·Vol. 199 ·No. 2 ·1979-06-27 ·Pages 177-96

Bugnon C, Bloch B, Lenys D, Fellmann D

Abstract

In man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can be stained with anti-endorphin (alpha and beta), anti-ACTH, anti-MSH (alpha and beta) and anti-beta-LPH immune sera (I.S.). In the fetus, certain neurons stain with anti-beta-endorphin or anti((17--39)ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons contain elementary granules that are immunoreactive with anti-beta-endorphin. In the adult, neurons immunoreactive with anti-beta-endorphin are found in the infundibular nucleus. Their axonal fibers terminate around blood vessels in the neurovascular zone and in the pituitary stalk, or establish contacts with non-immunoreactive perikarya of the infundibular nucleus. These neurons can be stained with anti(17--39)ACTH and anti-beta-endorphin I.S. The most reactive are also stained moderately with anti-alpha-MSH, anti-beta-MSH, anti-beta-LPH, anti-alpha-endorphin, or anti(1--24)ACTH I.S. These results indicate that, in man, compound(s) identical with or immunologically related to endorphins, beta-LPH, ACTH and MSH are secreted by certain hypothalamic neurons. These agents probably originate from a common precursor molecula similar to the so-called pro-opiocortin.

MeSH Terms
Adrenocorticotropic Hormone/immunology,metabolism Adult Antibodies Endorphins/immunology,metabolism Fetus/metabolism Humans Hypothalamus/metabolism Immunochemistry Infant, Newborn Melanocyte-Stimulating Hormones/immunology,metabolism Neurons/metabolism beta-Lipotropin/immunology,metabolism
Chemicals
Antibodies Endorphins Adrenocorticotropic Hormone Melanocyte-Stimulating Hormones beta-Lipotropin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bugnon C
Bloch B
Lenys D
Fellmann D
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56 references, click to expand
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00236130
Published
1979-06-27
Pages
177-96
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00236130 View journal details
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