Home LiteratureArticle Details
PMID: 22383838 Published · ppublish English Journal Article Comment

Cell signaling. Structural origins of receptor bias.

Science (New York, N.Y.) ·Vol. 335 ·No. 6072 ·2012-03-02 ·Pages 1055-6

Sprang SR, Elk JC

Abstract

暂无摘要

MeSH Terms
Adrenergic beta-2 Receptor Agonists/metabolism Receptors, Adrenergic, beta-2/chemistry,metabolism Signal Transduction
Chemicals
Adrenergic beta-2 Receptor Agonists Receptors, Adrenergic, beta-2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sprang Stephen R
Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT 59812, USA. stephen.sprang@umontana.edu
Elk Jackson Chief
References (15)
15 references, click to expand
  1. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.
    J Biol Chem. 2001 Jul 6;276(27):24433-6 PMID: 11320077
  2. Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.
    J Am Chem Soc. 2010 Aug 25;132(33):11443-5 PMID: 20669948
  3. β-Arrestin-mediated receptor trafficking and signal transduction.
    Trends Pharmacol Sci. 2011 Sep;32(9):521-33 PMID: 21680031
  4. Structure of an agonist-bound human A2A adenosine receptor.
    Science. 2011 Apr 15;332(6027):322-7 PMID: 21393508
  5. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
    Science. 2012 Mar 2;335(6072):1106-10 PMID: 22267580
  6. Crystal structure of the β2 adrenergic receptor-Gs protein complex.
    Nature. 2011 Jul 19;477(7366):549-55 PMID: 21772288
  7. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.
    Pharmacol Rev. 2010 Jun;62(2):265-304 PMID: 20392808
  8. The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.
    Nature. 2011 Jan 13;469(7329):241-4 PMID: 21228877
  9. Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.
    J Biol Chem. 2005 Jun 10;280(23):22165-71 PMID: 15817484
  10. Activation mechanism of the β2-adrenergic receptor.
    Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18684-9 PMID: 22031696
  11. Functional selectivity and classical concepts of quantitative pharmacology.
    J Pharmacol Exp Ther. 2007 Jan;320(1):1-13 PMID: 16803859
  12. The structure and function of G-protein-coupled receptors.
    Nature. 2009 May 21;459(7245):356-63 PMID: 19458711
  13. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
    Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62 PMID: 17925438
  14. Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
    Nat Chem Biol. 2006 Aug;2(8):417-22 PMID: 16799554
  15. Crystal structure of opsin in its G-protein-interacting conformation.
    Nature. 2008 Sep 25;455(7212):497-502 PMID: 18818650
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2012-03-02
Pages
1055-6
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3804247
Subset
IM
Grants
NIDDK NIH HHS · R56 DK046371 · United States
Corrections
CommentOn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com