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PMID: 22240970 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation of TOR by small GTPases.

EMBO reports ·Vol. 13 ·No. 2 ·2012-02-01 ·Pages 121-8

Durán RV, Hall MN

Abstract

TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.

MeSH Terms
Animals Humans Models, Biological Monomeric GTP-Binding Proteins/metabolism Signal Transduction TOR Serine-Threonine Kinases/metabolism
Chemicals
TOR Serine-Threonine Kinases Monomeric GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Durán Raúl V
Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
Hall Michael N
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-3178
DOI
10.1038/embor.2011.257
Published
2012-02-01
Epub
2012-00-01
Pages
121-8
Language
English
Region
England
NLM ID
100963049
PMCID
PMC3271343
Subset
IM
External Links
PubMed source DOI: 10.1038/embor.2011.257 PMC Full Text View journal details
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