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PMID: 21625337 Published · ppublish English Journal Article

Rab small GTPase emerges as a regulator of TOR complex 2.

Small GTPases ·Vol. 1 ·No. 3 ·2010-11-00 ·Pages 180-182

Tatebe H, Shiozaki K

Abstract

In diverse eukaryotic species from yeast to human, TOR (Target Of Rapamycin) protein kinase operates in signaling pathways that link extracellular stimuli to the control of cell growth and metabolism. TOR kinase functions in two distinct protein complexes, TOR complex 1 (TORC1) and 2 (TORC2). While TORC1 is known to be under the control of the Ras-like small GTPase Rheb, our knowledge about TORC2 regulation is very limited. We thus set out to identify TORC2 activators through genetic approaches in the fission yeast Schizosaccharomyces pombe. Here we briefly review our study that has identified a Rab-family GTPase, Ryh1 and its GEF (guanine nucleotide exchange factor) as positive regulators of TORC2 signaling in S. pombe. Considering the evolutionary conservation of the TOR pathways, it is conceivable that Rabfamily GTPases also play a role in the regulation of human TORC2 in cellular proliferation and insulin signaling.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tatebe Hisashi
Graduate School of Biological Sciences; Nara Institute of Science and Technology; Ikoma, Nara Japan.
Shiozaki Kazuhiro
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Article Info
Journal
Small GTPases
Abbr.
Small GTPases
ISSN
2154-1256
DOI
10.4161/sgtp.1.3.14936
Published
2010-11-00
Pages
180-182
Language
English
Region
United States
NLM ID
101530974
PMCID
PMC3103070
Grants
NIGMS NIH HHS · R01 GM059788 · United States
NIGMS NIH HHS · R01 GM059788-12 · United States
External Links
PubMed source DOI: 10.4161/sgtp.1.3.14936 PMC Full Text
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