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PMID: 22209238 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Directed cell invasion and migration during metastasis.

Current opinion in cell biology ·Vol. 24 ·No. 2 ·2012-04-00 ·Pages 277-83

Bravo-Cordero JJ, Hodgson L, Condeelis J

Abstract

Metastasis requires tumor cell dissemination to different organs from the primary tumor. Dissemination is a complex cell motility phenomenon that requires the molecular coordination of the protrusion, chemotaxis, invasion and contractility activities of tumor cells to achieve directed cell migration. Recent studies of the spatial and temporal activities of the small GTPases have begun to elucidate how this coordination is achieved. The direct visualization of the pathways involved in actin polymerization, invasion and directed migration in dissemination competent tumor cells will help identify the molecular basis of dissemination and allow the design and testing of more specific and selective drugs to block metastasis.

MeSH Terms
Animals Cell Membrane/metabolism,pathology Cell Movement Chemotaxis Cytoskeleton/metabolism,pathology Epithelial-Mesenchymal Transition Humans Neoplasm Invasiveness/pathology Neoplasm Metastasis/drug therapy,pathology Neoplasms/drug therapy,pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bravo-Cordero Jose Javier
Department of Anatomy and Structural Biology and Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, United States. jose-javier.bravo@einstein.yu.edu
Hodgson Louis
Condeelis John
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2011.12.004
Email
jose-javier.bravo@einstein.yu.edu
Published
2012-04-00
Epub
2011-00-30
Pages
277-83
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3320684
Subset
IM
Grants
NIGMS NIH HHS · GM093121 · United States
NIGMS NIH HHS · R01 GM093121 · United States
NIGMS NIH HHS · R01 GM093121-03 · United States
NCI NIH HHS · CA150344 · United States
NCI NIH HHS · R01 CA150344 · United States
NCI NIH HHS · R01 CA150344-24 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2011.12.004 PMC Full Text View journal details
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