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PMID: 21326322 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Nucleating actin for invasion.

Nature reviews. Cancer ·Vol. 11 ·No. 3 ·2011-03-00 ·Pages 177-87

Nürnberg A, Kitzing T, Grosse R

Abstract

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease.

MeSH Terms
Actins/genetics,metabolism Animals Cell Movement Humans Neoplasm Invasiveness Neoplasm Metastasis Neoplasms/genetics,metabolism,pathology,physiopathology
Chemicals
Actins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nürnberg Alexander
Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Str. 1, 35032 Marburg, Germany.
Kitzing Thomas
Grosse Robert
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3003
Published
2011-03-00
Epub
2011-00-10
Pages
177-87
Language
English
Region
England
NLM ID
101124168
Subset
IM
External Links
PubMed source DOI: 10.1038/nrc3003 View journal details
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