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PMID: 19219613 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness.

World journal of urology ·Vol. 27 ·No. 4 ·2009-08-00 ·Pages 557-63

Wang GC, Hsieh PS, Hsu HH, Sun GH, Nieh S, Yu CP, Jin JS

Abstract

We tested the hypothesis that the expression of cortactin and survivin in renal cell carcinomas (RCCs) correlates with more advanced stages of the disease. Immunohistochemical analysis of cortactin and survivin expression (scored on a scale of 0-400) was performed in 124 renal cell carcinomas including clear cell renal cell carcinoma (CRCC), papillary RCC (PRCC), CRCC with sarcomatoid differentiation (SRCC), chromophobe RCC (ChRCC), and CRCC with granular cell differentiation (GRCC). Higher cortactin scores in CRCC were significantly correlated with higher T (p = 0.021) and N stages (p = 0.036), and nuclear grade (p = 0.012). Higher cortactin immunostaining scores were associated with higher mortality (p = 0.035). In addition, the survivin scores were significantly higher in the more aggressive GRCC and SRCC than in CRCC, suggesting a significant role of survivin expression in transformation of tumor cells to a more malignant phenotype. Higher expression of cortactin and survivin significantly correlated with advanced clinicopathological stage. Our findings support the potential targeting of survivin and cortactin for the development of novel therapeutic strategies for renal cell carcinoma.

MeSH Terms
Biomarkers, Tumor Carcinoma, Renal Cell/diagnosis,metabolism,pathology Cortactin/metabolism Disease Progression Humans Inhibitor of Apoptosis Proteins Kidney Neoplasms/diagnosis,metabolism,pathology Microarray Analysis Microtubule-Associated Proteins/metabolism Middle Aged Neoplasm Staging Retrospective Studies Severity of Illness Index Survivin
Chemicals
BIRC5 protein, human Biomarkers, Tumor Cortactin Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Survivin
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Wang Giueng-Chueng
Department of Clinical Pathology, Tri-Service General Hospital and Taipei Medical University-Municipal Wan Fang Hospital, Taipei, Taiwan, ROC.
Hsieh Po-Shiuan
Hsu Hsian-He
Sun Guang-Huan
Nieh Shin
Yu Cheng-Ping
Jin Jong-Shiaw
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Article Info
Journal
World journal of urology
Abbr.
World J Urol
ISSN
1433-8726
DOI
10.1007/s00345-009-0376-2
Published
2009-08-00
Epub
2009-00-15
Pages
557-63
Language
English
Region
Germany
NLM ID
8307716
Subset
IM
External Links
PubMed source DOI: 10.1007/s00345-009-0376-2 View journal details
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