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PMID: 221925 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 5 ·1979-05-00 ·Pages 2442-6

Klein G

Abstract

Human B cell lymphoma and murine T cell leukemia can be initiated by several agents. The present paper formulates some thoughts on the role of cytogenetic changes in the subsequent neoplastic process. Initiation creates long-lived preneoplastic cells. In some respects, they are comparable to in vitro-transformed ("immortalized") cell lines that maintain a diploid karyotype and are not tumorigenic in vivo. The development of a tumorigenic ("autonomous") clone is dependent on additional changes at the genetic level. In human B and murine T cell lymphoma, there are characteristic nonrandom chromosomal changes. The 14q+ marker appears to play a key role in human B cell lymphomas. The reciprocal 8;14 translocation in Burkitt lymphoma is a specialized subclass within this category. In murine T cell leukemia, trisomy 15 is the predominant change. The clustering of these nonrandom changes to tumors derived from a certain cell type rather than to tumors induced by a given etiological agent has important implications for the understanding of the genetic control of cellular responsiveness to growth-regulating forces in vivo.

MeSH Terms
AKR murine leukemia virus Animals Burkitt Lymphoma/etiology Cell Transformation, Neoplastic Cell Transformation, Viral Genes, Viral Herpesvirus 4, Human Humans Leukemia, Experimental/etiology,genetics Lymphoma/etiology,genetics Mice Phenotype T-Lymphocytes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Klein G
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72 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.5.2442
Published
1979-05-00
Pages
2442-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC383618
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.5.2442 PMC Full Text View journal details
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