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PMID: 210392 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study.

Nature ·Vol. 274 ·No. 5673 ·1978-08-24 ·Pages 756-61

de-Thé G, Geser A, Day NE, Tukei PM, Williams EH, Beri DP, Smith PG, Dean AG, Bronkamm GW, Feorino P, Henle W

Abstract

Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titres to Epstein-Barr virus structural antigens are at high risk of developing Burkitt's lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt's lymphoma but suggest that the oncogenic potential of the virus is realised only in exceptional circumstances.

MeSH Terms

Age Factors Antibodies, Viral/analysis Burkitt Lymphoma/etiology,microbiology Child Child, Preschool Cocarcinogenesis Female Herpesvirus 4, Human/immunology Humans Malaria/complications Male Uganda

Chemicals

Antibodies, Viral

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

de-Thé G

Geser A

Day N E

Tukei P M

Williams E H

Beri D P

Smith P G

Dean A G

Bronkamm G W

Feorino P

Henle W

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/274756a0

Published

1978-08-24

Pages

756-61

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/274756a0 View journal details

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Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study.

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