Origin of the translocated segment of the 14q+ marker in non-Burkitt lymphomas.

Human genetics ·Vol. 36 ·No. 3 ·1977-05-10 ·Pages 277-82

Mark J, Ekedahl C, Hagman A

Abstract

The cytogenetic findings by G-banding in two histiocytic lymphomas are described. Both tumors had a stemline with a 14q+ marker. The origin of the extra segment on No. 14 was determined, and it was different in the two cases. These observations, and those from non-Burkitt lymphomas with 14q+ markers reported in the literature, indicate an inconsistent pattern for the origin of the extra material on No. 14. The only feature in common for all cases is instability of the distal region of the long arm of No. 14, and liability of this region to be involved in structural rearrangements, particularly translocations.

MeSH Terms

Biopsy Chromosomes, Human, 13-15 Female Humans Karyotyping Lymph Nodes/pathology Lymphoma, Large B-Cell, Diffuse/pathology Middle Aged Translocation, Genetic

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mark J

Ekedahl C

Hagman A

References (8)

8 references, click to expand

Histiocytic lymphomas with the marker chromosome 14q+.
Hereditas. 1975;81(2):289-92 PMID: 765305
Chromosomal abnormalities and their specificity in human neoplasms: an assessment of recent observations by banding techniques.
Adv Cancer Res. 1977;24:165-222 PMID: 322458
Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.
Int J Cancer. 1976 Jan 15;17(1):47-56 PMID: 946170
Specific marker chromosome 14 in malignant lymphomas.
Nature. 1976 Jan 22;259(5540):210-11 PMID: 765834
Somatic rearrangement of chromosome 14 in human lymphocytes.
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2071-5 PMID: 1056013
Marker chromosome 14q+ in two non-Burkitt lymphomas.
Humangenetik. 1975 Nov 6;30(2):109-12 PMID: 1242711
Cytogenetics of malignant lymphomas. Studies utilising a Giemsa-banding technique.
Humangenetik. 1973 Dec 10;20(3):231-50 PMID: 4772077
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Hereditas. 1976;83(1):47-56 PMID: 786957

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00446277

Published

1977-05-10

Pages

277-82

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00446277 View journal details

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Origin of the translocated segment of the 14q+ marker in non-Burkitt lymphomas.

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