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PMID: 2204819 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.

Molecular and cellular biology ·Vol. 10 ·No. 10 ·1990-10-00 ·Pages 5553-7

Yagle K, McEntee K

Abstract

The sequence of the DIN1 gene of Saccharomyces cerevisiae is identical to RNR3, a gene encoding a DNA damage-inducible regulatory subunit of ribonucleotide reductase. Two sequence elements located upstream of DIN1 (RNR3) are homologous to putative DNA damage regulatory elements in the promoter of the reductase catalytic subunit gene, RNR2. The transcript start sites for DIN1(RNR3) have been localized, and induction by different agents has been compared with other DNA damage-regulated genes.

MeSH Terms
Amino Acid Sequence Base Sequence DNA Damage Genes, Fungal Molecular Sequence Data Restriction Mapping Ribonucleoside Diphosphate Reductase/genetics Ribonucleotide Reductases/genetics Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins/genetics Transcription, Genetic
Chemicals
Saccharomyces cerevisiae Proteins Ribonucleotide Reductases RNR3 protein, S cerevisiae Ribonucleoside Diphosphate Reductase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yagle K
Laboratory of Biomedical and Environmental Sciences, UCLA School of Medicine 90024-1786.
McEntee K
References (15)
15 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.10.10.5553-5557.1990
Published
1990-10-00
Pages
5553-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC361273
Subset
IM
Grants
NIGMS NIH HHS · GM38456 · United States
Databases
GENBANK
M37684, M58012
External Links
PubMed source DOI: 10.1128/mcb.10.10.5553-5557.1990 PMC Full Text View journal details
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