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PMID: 3316984 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.

Molecular and cellular biology ·Vol. 7 ·No. 10 ·1987-10-00 ·Pages 3673-7

Hurd HK, Roberts CW, Roberts JW

Abstract

We have identified, cloned, and sequenced the gene for the small subunit of ribonucleotide diphosphate reductase of Saccharomyces cerevisiae. The protein and its transcript are induced about 10-fold by the alkylating agent methyl methanesulfonate, a result which suggests that the gene is induced by DNA damage.

MeSH Terms
Amino Acid Sequence Base Sequence Cloning, Molecular Cross Reactions DNA Damage Gene Expression Regulation/drug effects Genes Genes, Fungal Methyl Methanesulfonate/pharmacology Molecular Sequence Data Rec A Recombinases/genetics Ribonucleotide Reductases/genetics,immunology Saccharomyces cerevisiae/genetics Transcription, Genetic/drug effects
Chemicals
Methyl Methanesulfonate Ribonucleotide Reductases Rec A Recombinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hurd H K
Section of Biochemistry, Molecular & Cell Biology, Cornell University, Ithaca, New York 14853.
Roberts C W
Roberts J W
References (17)
17 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.10.3673-3677.1987
Published
1987-10-00
Pages
3673-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368022
Subset
IM
Grants
NIGMS NIH HHS · GM 21941 · United States
Databases
GENBANK
M17789
External Links
PubMed source DOI: 10.1128/mcb.7.10.3673-3677.1987 PMC Full Text View journal details
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