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PMID: 2177521 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria.

Molecular & general genetics : MGG ·Vol. 224 ·No. 1 ·1990-10-00 ·Pages 111-8

Decoster E, Simon M, Hatat D, Faye G

Abstract

The MSS51 gene product has been previously shown to be involved in the splicing of the mitochondrial pre-mRNA of cytochrome oxidase subunit I (COX1). We show here that it is specifically required for the translation of the COX1 mRNA. Furthermore, the paromocyin-resistance mutation (P454R) which affects the 15S mitoribosomal RNA, interferes, directly or indirectly, with the action of the MSS51 gene product. Possible roles of the MSS51 protein on the excision of COX1 introns are discussed.

Related Genes
COX1 MSS51
MeSH Terms
Alleles Blotting, Northern Drug Resistance, Microbial/genetics Electron Transport Complex IV/genetics,metabolism Fungal Proteins/metabolism Mitochondria/metabolism Paromomycin/pharmacology Protein Biosynthesis RNA, Fungal/genetics,metabolism RNA, Messenger/genetics,metabolism Restriction Mapping Saccharomyces cerevisiae/enzymology,genetics,growth & development
Chemicals
Fungal Proteins RNA, Fungal RNA, Messenger Paromomycin Electron Transport Complex IV
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Decoster E
Institut Curie, Section de Biologie, Orsay, France.
Simon M
Hatat D
Faye G
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23 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00259457
Published
1990-10-00
Pages
111-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00259457
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