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PMID: 21666272 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Using BioMart as a framework to manage and query pancreatic cancer data.

Database : the journal of biological databases and curation ·Vol. 2011 ·2011-00-00 ·Pages bar024

Cutts RJ, Gadaleta E, Lemoine NR, Chelala C

Abstract

We describe the Pancreatic Expression Database (PED), the first cancer database originally designed based on the BioMart infrastructure. The PED portal brings together multidimensional pancreatic cancer data from the literature including genomic, proteomic, miRNA and gene expression profiles. Based on the BioMart 0.7 framework, the database is easily integrated with other BioMart-compliant resources, such as Ensembl and Reactome, to give access to a wide range of annotations alongside detailed experimental conditions. This article is intended to give an overview of PED, describe its data content and work through examples of how to successfully mine and integrate pancreatic cancer data sets and other BioMart resources.

MeSH Terms
Computational Biology/methods DNA Copy Number Variations/genetics Database Management Systems Databases, Genetic Gene Expression Regulation, Neoplastic Humans Internet MicroRNAs/genetics Pancreatic Neoplasms/genetics Search Engine Software
Chemicals
MicroRNAs
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cutts Rosalind J
Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Gadaleta Emanuela
Lemoine Nicholas R
Chelala Claude
References (17)
17 references, click to expand
  1. The Pancreatic Expression database: 2011 update.
    Nucleic Acids Res. 2011 Jan;39(Database issue):D1023-8 PMID: 20959292
  2. The distributed annotation system.
    BMC Bioinformatics. 2001;2:7 PMID: 11667947
  3. Integration of biological networks and gene expression data using Cytoscape.
    Nat Protoc. 2007;2(10):2366-82 PMID: 17947979
  4. Galaxy: a platform for interactive large-scale genome analysis.
    Genome Res. 2005 Oct;15(10):1451-5 PMID: 16169926
  5. International network of cancer genome projects.
    Nature. 2010 Apr 15;464(7291):993-8 PMID: 20393554
  6. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer.
    Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50 PMID: 20952405
  7. BioMart Central Portal--unified access to biological data.
    Nucleic Acids Res. 2009 Jul;37(Web Server issue):W23-7 PMID: 19420058
  8. Ensembl 2009.
    Nucleic Acids Res. 2009 Jan;37(Database issue):D690-7 PMID: 19033362
  9. Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets.
    BMC Genomics. 2007 Nov 28;8:439 PMID: 18045474
  10. Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent.
    J Pathol. 2003 Sep;201(1):63-74 PMID: 12950018
  11. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions.
    Am J Surg Pathol. 2001 May;25(5):579-86 PMID: 11342768
  12. S100P is a novel marker to identify intraductal papillary mucinous neoplasms.
    Hum Pathol. 2010 Jun;41(6):824-31 PMID: 20153506
  13. Update on pancreatic intraepithelial neoplasia.
    Int J Clin Exp Pathol. 2008 Jan 01;1(4):306-16 PMID: 18787611
  14. Reactome knowledgebase of human biological pathways and processes.
    Nucleic Acids Res. 2009 Jan;37(Database issue):D619-22 PMID: 18981052
  15. Online resources of cancer data: barriers, benefits and lessons.
    Brief Bioinform. 2011 Jan;12(1):52-63 PMID: 20348133
  16. Genomic databases and resources at the National Center for Biotechnology Information.
    Methods Mol Biol. 2010;609:17-44 PMID: 20221911
  17. A web-based platform for mining pancreatic expression datasets.
    Pancreatology. 2009;9(4):340-3 PMID: 19451743
Article Info
Journal
Database : the journal of biological databases and curation
Abbr.
Database (Oxford)
ISSN
1758-0463
Published
2011-00-00
Epub
2011-00-11
Pages
bar024
Language
English
Region
England
NLM ID
101517697
PMCID
PMC3114646
Subset
IM
Grants
Cancer Research UK · 12008 · United Kingdom
Cancer Research UK · C355/A6253 · United Kingdom
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