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PMID: 21654818 Published · epublish English Journal Article Review

SWI/SNF nucleosome remodellers and cancer.

Nature reviews. Cancer ·Vol. 11 ·No. 7 ·2011-06-09 ·Pages 481-92

Wilson BG, Roberts CW

Abstract

SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in several SWI/SNF subunits have recently been identified at a high frequency in a variety of cancers. However, the mechanisms by which mutations in these complexes drive tumorigenesis are unclear. In this Review we discuss the contributions of SWI/SNF mutations to cancer formation, examine their normal functions and discuss opportunities for novel therapeutic interventions for SWI/SNF-mutant cancers.

MeSH Terms
Animals Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone/genetics,physiology DNA Helicases/genetics,physiology DNA-Binding Proteins/genetics,physiology Humans Mutation Neoplasms/etiology,genetics Nuclear Proteins/genetics,physiology Nucleosomes/physiology SMARCB1 Protein Transcription Factors/genetics,physiology
Chemicals
ARID1A protein, human Chromosomal Proteins, Non-Histone DNA-Binding Proteins Nuclear Proteins Nucleosomes PBRM1 protein, human SMARCB1 Protein SMARCB1 protein, human Transcription Factors SMARCA4 protein, human DNA Helicases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilson Boris G
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Roberts Charles W M
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3068
Published
2011-06-09
Epub
2011-00-09
Pages
481-92
Language
English
Region
England
NLM ID
101124168
Subset
IM
External Links
PubMed source DOI: 10.1038/nrc3068 View journal details
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