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PMID: 17822959 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.

Trends in molecular medicine ·Vol. 13 ·No. 9 ·2007-09-00 ·Pages 373-80

Wang GG, Allis CD, Chi P

Abstract

Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in part I) underlie many fundamental cellular processes, including transcriptional regulation and DNA-damage repair. Dysregulation of these processes has been linked to cancer development. Mechanisms of chromatin remodeling include dynamic interplay between ATP-dependent complexes, covalent histone modifications, utilization of histone variants and DNA methylation. In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer.

MeSH Terms
Adenosine Triphosphate/metabolism,physiology Animals Chromatin/metabolism,physiology Histones/chemistry,metabolism Humans Models, Biological Neoplasms/metabolism,physiopathology Protein Processing, Post-Translational
Chemicals
Chromatin Histones Adenosine Triphosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wang Gang G
Laboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Allis C David
Chi Ping
References (67)
67 references, click to expand
  1. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.
    Cancer Res. 2003 Feb 1;63(3):560-6 PMID: 12566296
  2. Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.
    Mol Cell Biol. 2001 May;21(10 ):3598-603 PMID: 11313485
  3. Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.
    Nat Struct Mol Biol. 2006 Oct;13(10):902-7 PMID: 17013386
  4. Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).
    EMBO J. 1998 Dec 1;17(23):6979-91 PMID: 9843504
  5. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
    Cell. 2004 Oct 1;119(1):75-86 PMID: 15454082
  6. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
    J Biol Chem. 2005 Dec 16;280(50):41207-12 PMID: 16230350
  7. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.
    Nature. 1998 Jul 9;394(6689):203-6 PMID: 9671307
  8. Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.
    Genes Dev. 2005 Mar 15;19(6):665-70 PMID: 15769941
  9. Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
    Biochim Biophys Acta. 2004 Mar 15;1677(1-3):113-9 PMID: 15020052
  10. Connections between epigenetic gene silencing and human disease.
    Mutat Res. 2007 May 1;618(1-2):163-74 PMID: 17306846
  11. SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas.
    Cancer Res. 2005 May 15;65(10 ):4012-9 PMID: 15899790
  12. DNA methylation and human disease.
    Nat Rev Genet. 2005 Aug;6(8):597-610 PMID: 16136652
  13. The INO80 protein controls homologous recombination in Arabidopsis thaliana.
    Mol Cell. 2004 Nov 5;16(3):479-85 PMID: 15525519
  14. Chromatin assembly by DNA-translocating motors.
    Nat Rev Mol Cell Biol. 2003 Aug;4(8):613-20 PMID: 12923523
  15. Chromatin remodeling factor encoded by ini1 induces G1 arrest and apoptosis in ini1-deficient cells.
    Oncogene. 2002 May 9;21(20):3112-20 PMID: 12082626
  16. Recent advances in understanding chromatin remodeling by Swi/Snf complexes.
    Curr Opin Genet Dev. 2003 Apr;13(2):136-42 PMID: 12672490
  17. The epigenomics of cancer.
    Cell. 2007 Feb 23;128(4):683-92 PMID: 17320506
  18. The SANT domain: a unique histone-tail-binding module?
    Nat Rev Mol Cell Biol. 2004 Feb;5(2):158-63 PMID: 15040448
  19. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
    Cell. 2003 Apr 18;113(2):207-19 PMID: 12705869
  20. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.
    Mol Cell Biol. 2002 Mar;22(5):1307-16 PMID: 11839798
  21. Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair.
    Genes Dev. 2005 Jul 15;19(14):1656-61 PMID: 16024655
  22. Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae.
    Nature. 2005 Nov 17;438(7066):379-83 PMID: 16292314
  23. A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.
    Oncogene. 2002 Sep 19;21(42):6403-12 PMID: 12226744
  24. ATP-dependent nucleosome remodeling.
    Annu Rev Biochem. 2002;71:247-73 PMID: 12045097
  25. Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.
    Mol Cell. 2004 Dec 22;16(6):979-90 PMID: 15610740
  26. Mi-2/NuRD: multiple complexes for many purposes.
    Biochim Biophys Acta. 2004 Mar 15;1677(1-3):52-7 PMID: 15020045
  27. CHD5 is a tumor suppressor at human 1p36.
    Cell. 2007 Feb 9;128(3):459-75 PMID: 17289567
  28. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
    Nature. 2006 Jul 6;442(7098):86-90 PMID: 16728976
  29. Regulated nucleosome mobility and the histone code.
    Nat Struct Mol Biol. 2004 Nov;11(11):1037-43 PMID: 15523479
  30. The hallmarks of cancer.
    Cell. 2000 Jan 7;100(1):57-70 PMID: 10647931
  31. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.
    J Biol Chem. 2005 Dec 23;280(51):41789-92 PMID: 16263726
  32. How does the histone code work?
    Biochem Cell Biol. 2005 Aug;83(4):468-76 PMID: 16094450
  33. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
    Nat Rev Cancer. 2006 Feb;6(2):107-16 PMID: 16491070
  34. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex.
    Mol Cell. 2004 Nov 5;16(3):465-77 PMID: 15525518
  35. Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.
    Mol Cell Biol. 2006 Apr;26(7):2661-74 PMID: 16537910
  36. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.
    Nat Genet. 2006 May;38(5):540-9 PMID: 16642018
  37. Novel germ-line deletion of SNF5/INI1/SMARCB1 gene in neonate presenting with congenital malignant rhabdoid tumor of kidney and brain primitive neuroectodermal tumor.
    Genes Chromosomes Cancer. 2004 Jun;40(2):133-9 PMID: 15101046
  38. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
    Nature. 2007 Aug 9;448(7154):714-7 PMID: 17687327
  39. The SWI/SNF complex--chromatin and cancer.
    Nat Rev Cancer. 2004 Feb;4(2):133-42 PMID: 14964309
  40. The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.
    EMBO Rep. 2000 Dec;1(6):500-6 PMID: 11263494
  41. BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression.
    J Biol Chem. 2006 Dec 22;281(51):38974-80 PMID: 17023429
  42. Epigenetic stem cell signature in cancer.
    Nat Genet. 2007 Feb;39(2):157-8 PMID: 17200673
  43. Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma.
    Oncogene. 2005 Apr 14;24(16):2684-94 PMID: 15829979
  44. Biological functions of the ISWI chromatin remodeling complex NURF.
    Genes Dev. 2002 Dec 15;16(24):3186-98 PMID: 12502740
  45. A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.
    Nature. 2002 Aug 8;418(6898):654-7 PMID: 12167865
  46. H2AX: the histone guardian of the genome.
    DNA Repair (Amst). 2004 Aug-Sep;3(8-9):959-67 PMID: 15279782
  47. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.
    Cell. 2000 Jul 21;102(2):257-65 PMID: 10943845
  48. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.
    Cancer Cell. 2002 Nov;2(5):415-25 PMID: 12450796
  49. SnapShot: chromatin remodeling complexes.
    Cell. 2007 May 4;129(3):632 PMID: 17482554
  50. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.
    Science. 2004 Jan 16;303(5656):343-8 PMID: 14645854
  51. Chromatin remodeling in DNA double-strand break repair.
    Curr Opin Genet Dev. 2007 Apr;17(2):126-31 PMID: 17320375
  52. INO80 subfamily of chromatin remodeling complexes.
    Mutat Res. 2007 May 1;618(1-2):18-29 PMID: 17316710
  53. Mechanisms of ATP dependent chromatin remodeling.
    Mutat Res. 2007 May 1;618(1-2):3-17 PMID: 17306844
  54. CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system.
    Oncogene. 2003 Feb 20;22(7):1002-11 PMID: 12592387
  55. Stem cell self-renewal controlled by chromatin remodeling factors.
    Science. 2005 Dec 2;310(5753):1487-9 PMID: 16322456
  56. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.
    Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800 PMID: 11095756
  57. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.
    Cell. 2004 Dec 17;119(6):767-75 PMID: 15607974
  58. Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.
    Cell. 2003 Nov 14;115(4):425-35 PMID: 14622597
  59. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.
    Mol Cell. 2000 Dec;6(6):1287-95 PMID: 11163203
  60. Double chromodomains cooperate to recognize the methylated histone H3 tail.
    Nature. 2005 Dec 22;438(7071):1181-5 PMID: 16372014
  61. P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells.
    J Biol Chem. 2004 Jan 30;279(5):3807-16 PMID: 14604992
  62. Chromatin remodeling and cancer, Part I: Covalent histone modifications.
    Trends Mol Med. 2007 Sep;13(9):363-72 PMID: 17822958
  63. Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.
    J Biol Chem. 2005 Nov 25;280(47):39436-47 PMID: 16186106
  64. Chromatin remodelling: the industrial revolution of DNA around histones.
    Nat Rev Mol Cell Biol. 2006 Jun;7(6):437-47 PMID: 16723979
  65. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.
    Nat Cell Biol. 2006 Mar;8(3):285-92 PMID: 16462733
  66. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.
    Cell. 2004 Dec 17;119(6):777-88 PMID: 15607975
  67. Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.
    Cell. 2002 Nov 1;111(3):369-79 PMID: 12419247
Article Info
Journal
Trends in molecular medicine
Abbr.
Trends Mol Med
ISSN
1471-4914
DOI
10.1016/j.molmed.2007.07.004
Published
2007-09-00
Epub
2007-00-05
Pages
373-80
Language
English
Region
England
NLM ID
100966035
PMCID
PMC4337864
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040922 · United States
NCI NIH HHS · T32 CA009207 · United States
NCI NIH HHS · 5T32CA009207-28 · United States
External Links
PubMed source DOI: 10.1016/j.molmed.2007.07.004 PMC Full Text View journal details
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