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PMID: 21637017 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Life at the margins: modulation of attachment proteins in Helicobacter pylori.

Gut microbes ·Vol. 2 ·No. 1 ·2011-00-00 ·Pages 42-6

Moore ME, Borén T, Solnick JV

Abstract

Helicobacter pylori is the primary cause of peptic ulcer disease and is estimated to account for about 60% of all cases of gastric cancer, the second most common cause of cancer death worldwide. Among the H. pylori virulence factors associated with disease, in addition to the well-known cag pathogenicity island, is the BabA adhesin, an outer membrane protein that binds with high affinity to fucosylated glycans on the gastric epithelium, such as Lewis B (Le(b)) and related terminal fucose residues found on the blood group O (H antigen), A and B antigens. BabA-mediated attachment to the gastric mucosa promotes chronic inflammation and gastric pathology, which from the bacterial perspective carries both risks and benefits. We recently described modulation in expression of BabA and related outer membrane proteins that occurs during colonization of experimental animals. Here we put these findings into a broader context, and speculate on their implications for the host-pathogen relationship.

MeSH Terms
ABO Blood-Group System/chemistry,metabolism Adhesins, Bacterial/genetics,metabolism Animals Bacterial Adhesion Bacterial Outer Membrane Proteins/genetics,metabolism Fucose/metabolism Gastric Mucosa/immunology,microbiology Gene Expression Regulation, Bacterial Helicobacter Infections/microbiology Helicobacter pylori/immunology,pathogenicity,physiology Host-Pathogen Interactions Humans Lewis Blood Group Antigens/chemistry,metabolism Mice
Chemicals
ABO Blood-Group System Adhesins, Bacterial BabA protein, Helicobacter pylori Bacterial Outer Membrane Proteins Lewis Blood Group Antigens Fucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Moore Mary E
Department of Medicine, Center for Comparative Medicine, California National Primate Research Center, University of California, Davis School of Medicine, Davis, CA 95616, USA.
Borén Thomas
Solnick Jay V
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Article Info
Journal
Gut microbes
Abbr.
Gut Microbes
ISSN
1949-0984
DOI
10.4161/gmic.2.1.14626
Published
2011-00-00
Pages
42-6
Language
English
Region
United States
NLM ID
101495343
PMCID
PMC3225796
Subset
IM
Grants
NIAID NIH HHS · R01 AI070803 · United States
NIAID NIH HHS · R01 AI081037 · United States
NIAID NIH HHS · AI081037 · United States
NIAID NIH HHS · AI070803 · United States
External Links
PubMed source DOI: 10.4161/gmic.2.1.14626 PMC Full Text View journal details
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