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PMID: 21570275 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between.

Current opinion in cell biology ·Vol. 23 ·No. 4 ·2011-08-00 ·Pages 452-7

Babst M

Abstract

Multivesicular bodies (MVBs) are endosomes that have internalized portions of the limiting membrane into the compartment, thereby forming intralumenal vesicles. This vesicle formation is unusual in that it is directed away from the cytoplasm, which requires a unique mechanism unlike any mechanism described for other vesicle formation events. The best contenders for the machinery that drives MVB vesicle formation are the ESCRT protein complexes. However, increasing evidence suggests that lipids may play a key role in this membrane-deformation process. This review attempts to combine the seemingly contradictory findings into a MVB vesicle formation model that is based on a lipid-driven and ESCRT-regulated mechanism.

MeSH Terms
Animals Endosomal Sorting Complexes Required for Transport/metabolism Endosomes/metabolism Humans Lipid Metabolism Membrane Microdomains/metabolism Multivesicular Bodies/metabolism Protein Transport Secretory Pathway Yeasts/cytology,metabolism
Chemicals
Endosomal Sorting Complexes Required for Transport
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Babst Markus
University of Utah, Department of Biology, 257 South 1400 East, Salt Lake City, UT 84112, USA. babst@biology.utah.edu
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2011.04.008
Email
babst@biology.utah.edu
Published
2011-08-00
Epub
2011-00-11
Pages
452-7
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3148405
Subset
IM
Grants
NIGMS NIH HHS · R01 GM074171 · United States
NIGMS NIH HHS · R01 GM074171-06 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2011.04.008 PMC Full Text View journal details
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