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PMID: 21330364 Published · ppublish English Journal Article Review

DENN domain proteins: regulators of Rab GTPases.

The Journal of biological chemistry ·Vol. 286 ·No. 16 ·2011-04-22 ·Pages 13791-800

Marat AL, Dokainish H, McPherson PS

Abstract

The DENN domain is a common, evolutionarily ancient, and conserved protein module, yet it has gone largely unstudied; until recently, little was known regarding its functional roles. New studies reveal that various DENN domains interact directly with members of the Rab family of small GTPases and that DENN domains function enzymatically as Rab-specific guanine nucleotide exchange factors. Thus, DENN domain proteins appear to be generalized regulators of Rab function. Study of these proteins will provide new insights into Rab-mediated membrane trafficking pathways.

MeSH Terms
Amino Acid Motifs Amino Acid Sequence Animals Cell Membrane/metabolism Endocytosis Genome, Human Guanine Nucleotide Exchange Factors/metabolism Humans Mice Molecular Sequence Data Protein Binding Protein Structure, Tertiary Sequence Homology, Amino Acid Signal Transduction rab GTP-Binding Proteins/chemistry
Chemicals
Guanine Nucleotide Exchange Factors rab GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Marat Andrea L
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Dokainish Hatem
McPherson Peter S
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Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
1083-351X
DOI
10.1074/jbc.R110.217067
Published
2011-04-22
Epub
2011-00-17
Pages
13791-800
Language
English
Region
United States
NLM ID
2985121R
PMCID
PMC3077579
Subset
IM
External Links
PubMed source DOI: 10.1074/jbc.R110.217067 PMC Full Text View journal details
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