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PMID: 21307847 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda.

Mucosal immunology ·Vol. 4 ·No. 4 ·2011-07-00 ·Pages 371-82

Griffin AJ, McSorley SJ

Abstract

Salmonella infections can cause a range of intestinal and systemic diseases in human and animal hosts. Although some Salmonella serovars initiate a localized intestinal inflammatory response, others use the intestine as a portal of entry to initiate a systemic infection. Considerable progress has been made in understanding bacterial invasion and dissemination strategies, as well as the nature of the Salmonella-specific immune response to oral infection. Innate and adaptive immunity are rapidly initiated after oral infection, but these effector responses can also be hindered by bacterial evasion strategies. Furthermore, although Salmonella resides within intramacrophage phagosomes, recent studies have highlighted a surprising collaboration of CD4 Th1, Th17, and B-cell responses in mediating resistance to Salmonella infection.

MeSH Terms
Adaptive Immunity/immunology Animals Disease Models, Animal Humans Immunity, Innate/immunology Mice Mucous Membrane/immunology,microbiology Salmonella/immunology Salmonella Infections/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Griffin A J
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Center for Infectious Diseases and Microbiology Translational Research, McGuire Translational Research Facility, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
McSorley S J
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Article Info
Journal
Mucosal immunology
Abbr.
Mucosal Immunol
ISSN
1935-3456
DOI
10.1038/mi.2011.2
Published
2011-07-00
Epub
2011-00-09
Pages
371-82
Language
English
Region
United States
NLM ID
101299742
PMCID
PMC4084725
Subset
IM
Grants
NIAID NIH HHS · P01 AI056172 · United States
NIAID NIH HHS · R01 AI055743 · United States
NIAID NIH HHS · AI055743 · United States
NIAID NIH HHS · AI56172 · United States
External Links
PubMed source DOI: 10.1038/mi.2011.2 PMC Full Text View journal details
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