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PMID: 20014951 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Global trends in typhoid and paratyphoid Fever.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America ·Vol. 50 ·No. 2 ·2010-01-15 ·Pages 241-6

Crump JA, Mintz ED

Abstract

Typhoid and paratyphoid fever continue to be important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, where enteric fever is associated with poor sanitation and unsafe food and water. High-quality incidence data from Asia are underpinning efforts to expand access to typhoid vaccines. Efforts are underway to develop vaccines that are immunogenic in infants after a single dose and that can be produced locally in countries of endemicity. The growing importance of Salmonella enterica serotype Paratyphi A in Asia is concerning. Antimicrobial resistance has sequentially emerged to traditional first-line drugs, fluoroquinolones, and third-generation cephalosporins, posing patient treatment challenges. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The availability of full genome sequences for S. enterica serotype Typhi and S. enterica serotype Paratyphi A confirms their place as monomorphic, human-adapted pathogens vulnerable to control measures if international efforts can be redoubled.

MeSH Terms
Drug Resistance, Bacterial Global Health Humans Paratyphoid Fever/drug therapy,epidemiology,prevention & control Typhoid Fever/drug therapy,epidemiology,prevention & control
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crump John A
Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. jcrump@cdc.gov
Mintz Eric D
References (52)
52 references, click to expand
  1. Multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica (serotypes Typhi and Paratyphi A) from blood isolates in Nepal: surveillance of resistance and a search for newer alternatives.
    Int J Infect Dis. 2006 Nov;10(6):434-8 PMID: 16978898
  2. Antimicrobial resistance in typhoidal and nontyphoidal salmonellae.
    Curr Opin Infect Dis. 2008 Oct;21(5):531-8 PMID: 18725804
  3. Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States foodnet multicenter retrospective cohort study.
    Antimicrob Agents Chemother. 2008 Apr;52(4):1278-84 PMID: 18212096
  4. Typhoid fever in the United States, 1999-2006.
    JAMA. 2009 Aug 26;302(8):859-65 PMID: 19706859
  5. Rethinking typhoid fever vaccines: implications for travelers and people living in highly endemic areas.
    J Travel Med. 2009 Jan-Feb;16(1):46-52 PMID: 19192128
  6. Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old.
    Infect Genet Evol. 2002 Oct;2(1):39-45 PMID: 12797999
  7. Surveillance of antimicrobial resistance of Salmonella enterica serotype Typhi in seven Asian countries.
    Epidemiol Infect. 2009 Feb;137(2):266-9 PMID: 18474127
  8. A cluster-randomized effectiveness trial of Vi typhoid vaccine in India.
    N Engl J Med. 2009 Jul 23;361(4):335-44 PMID: 19625715
  9. Reevaluating fluoroquinolone breakpoints for Salmonella enterica serotype Typhi and for non-Typhi salmonellae.
    Clin Infect Dis. 2003 Jul 1;37(1):75-81 PMID: 12830411
  10. Ciprofloxacin-resistant Salmonella typhi and treatment failure.
    Lancet. 1999 May 8;353(9164):1590-1 PMID: 10334265
  11. Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.
    J Bacteriol. 2003 Apr;185(7):2330-7 PMID: 12644504
  12. Typhoid vaccines: WHO position paper.
    Wkly Epidemiol Rec. 2008 Feb 8;83(6):49-59 PMID: 18260212
  13. Summary of an international workshop on typhoid fever.
    Rev Infect Dis. 1986 May-Jun;8(3):329-49 PMID: 3726393
  14. Evaluation of community-based serologic screening for identification of chronic Salmonella typhi carriers in Vietnam.
    Int J Infect Dis. 2006 Jul;10(4):309-14 PMID: 16412678
  15. A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam.
    PLoS One. 2008 May 21;3(5):e2188 PMID: 18493312
  16. Salmonella paratyphi A rates, Asia.
    Emerg Infect Dis. 2005 Nov;11(11):1764-6 PMID: 16318734
  17. Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever).
    Cochrane Database Syst Rev. 2008 Oct 08;(4):CD006083 PMID: 18843701
  18. Emerging trends in enteric fever in Nepal: 9124 cases confirmed by blood culture 1993-2003.
    Trans R Soc Trop Med Hyg. 2008 Jan;102(1):91-5 PMID: 18023462
  19. Urgent need for effective vaccine against Salmonella paratyphi A, B and C.
    Vaccine. 1995 Dec;13(17):1727-8 PMID: 8719526
  20. Re-emergence of chloramphenicol-sensitive Salmonella typhi.
    Lancet. 1999 Apr 10;353(9160):1241-2 PMID: 10217089
  21. Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens.
    Annu Rev Microbiol. 2008;62:53-70 PMID: 18785837
  22. Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance.
    Clin Infect Dis. 2008 Jun 1;46(11):1656-63 PMID: 18422453
  23. An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever.
    PLoS One. 2007 Jun 27;2(6):e542 PMID: 17593957
  24. Extended-spectrum-beta-lactamase production in a Salmonella enterica serotype Typhi strain from the Philippines.
    J Clin Microbiol. 2008 Aug;46(8):2794-5 PMID: 18550740
  25. Emergence of Salmonella enterica serotype Paratyphi A as a major cause of enteric fever in Kathmandu, Nepal.
    Trans R Soc Trop Med Hyg. 2006 Nov;100(11):1063-7 PMID: 16714040
  26. The global burden of typhoid fever.
    Bull World Health Organ. 2004 May;82(5):346-53 PMID: 15298225
  27. Part I. Analysis of data gaps pertaining to Salmonella enterica serotype Typhi infections in low and medium human development index countries, 1984-2005.
    Epidemiol Infect. 2008 Apr;136(4):436-48 PMID: 17686194
  28. Clinical microbiology in developing countries.
    Emerg Infect Dis. 2001 Mar-Apr;7(2):302-5 PMID: 11294729
  29. Multidrug-resistant Salmonella strains expressing emerging antibiotic resistance determinants.
    Clin Infect Dis. 2008 Jan 15;46(2):324-5 PMID: 18171274
  30. CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression.
    Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S20-3 PMID: 17582563
  31. Estimating the incidence of typhoid fever and other febrile illnesses in developing countries.
    Emerg Infect Dis. 2003 May;9(5):539-44 PMID: 12737736
  32. Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi.
    BMC Genomics. 2009 Jan 21;10:36 PMID: 19159446
  33. Identification of a carrier by using Vi enzyme-linked immunosorbent assay serology in an outbreak of typhoid fever on an Indian reservation.
    J Clin Microbiol. 1983 Dec;18(6):1320-2 PMID: 6655039
  34. Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.
    Nature. 2001 Oct 25;413(6858):848-52 PMID: 11677608
  35. Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: implications for rational design of typhoid fever vaccines.
    Vaccine. 2008 Dec 2;26(51):6639-44 PMID: 18834913
  36. Enteric fever in Israeli travelers: a nationwide study.
    J Travel Med. 2005 Sep-Oct;12(5):275-81 PMID: 16256052
  37. The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children.
    N Engl J Med. 2001 Apr 26;344(17):1263-9 PMID: 11320385
  38. Typhoid vaccination: the Asian experience.
    Expert Rev Vaccines. 2008 Jul;7(5):547-60 PMID: 18564010
  39. Evaluation of rapid diagnostic tests for typhoid fever.
    J Clin Microbiol. 2004 May;42(5):1885-9 PMID: 15131144
  40. Serodiagnosis of Salmonella enterica serovar Typhi and S. enterica serovars Paratyphi A, B and C human infections.
    J Med Microbiol. 2007 Sep;56(Pt 9):1161-1166 PMID: 17761477
  41. Mutations of the gyrA gene of clinical isolates of Salmonella typhimurium and three other Salmonella species leading to decreased susceptibilities to 4-quinolone drugs.
    J Antimicrob Chemother. 1996 Feb;37(2):351-6 PMID: 8707746
  42. A study of typhoid fever in five Asian countries: disease burden and implications for controls.
    Bull World Health Organ. 2008 Apr;86(4):260-8 PMID: 18438514
  43. Interventions to improve water quality for preventing diarrhoea: systematic review and meta-analysis.
    BMJ. 2007 Apr 14;334(7597):782 PMID: 17353208
  44. Ty21a live oral typhoid vaccine and prevention of paratyphoid fever caused by Salmonella enterica Serovar Paratyphi B.
    Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S24-8 PMID: 17582564
  45. An outbreak of peritonitis caused by multidrug-resistant Salmonella Typhi in Kinshasa, Democratic Republic of Congo.
    Travel Med Infect Dis. 2009 Jan;7(1):40-3 PMID: 19174300
  46. Mass vaccination to control epidemic and endemic typhoid fever.
    Curr Top Microbiol Immunol. 2006;304:231-46 PMID: 16989273
  47. Multidrug-resistant Salmonella typhi: a worldwide epidemic.
    Clin Infect Dis. 1997 Jan;24 Suppl 1:S106-9 PMID: 8994789
  48. An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine.
    J Infect Dis. 2001 Jun 15;183(12):1775-80 PMID: 11372030
  49. The use of typhoid vaccines in Asia: the DOMI experience.
    Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S34-8 PMID: 17582567
  50. Relative efficacy of blood, urine, rectal swab, bone-marrow, and rose-spot cultures for recovery of Salmonella typhi in typhoid fever.
    Lancet. 1975 May 31;1(7918):1211-3 PMID: 48834
  51. Typhoid fever in children in Africa.
    Trop Med Int Health. 2008 Apr;13(4):532-40 PMID: 18312473
  52. Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid.
    Nat Genet. 2004 Dec;36(12):1268-74 PMID: 15531882
Article Info
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Abbr.
Clin Infect Dis
ISSN
1537-6591
DOI
10.1086/649541
Email
jcrump@cdc.gov
Published
2010-01-15
Pages
241-6
Language
English
Region
United States
NLM ID
9203213
PMCID
PMC2798017
Subset
IM
Grants
NIAID NIH HHS · U01 AI062563-04 · United States
NIAID NIH HHS · U01 AI069484 · United States
NIAID NIH HHS · U01 AI062563 · United States
NIAID NIH HHS · P30 AI064518-05 · United States
NIAID NIH HHS · UM1 AI069484 · United States
NIAID NIH HHS · U01 AI069484-03 · United States
NIAID NIH HHS · AI64518 · United States
NIAID NIH HHS · AI069484-01 · United States
NIAID NIH HHS · AI062563 · United States
NIAID NIH HHS · P30 AI064518 · United States
FIC NIH HHS · D43 TW006732-04 · United States
External Links
PubMed source DOI: 10.1086/649541 PMC Full Text View journal details
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