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PMID: 12797999 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases ·Vol. 2 ·No. 1 ·2002-10-00 ·Pages 39-45

Kidgell C, Reichard U, Wain J, Linz B, Torpdahl M, Dougan G, Achtman M

Abstract

A global collection of 26 isolates of Salmonella typhi was investigated by sequencing a total of 3336 bp in seven housekeeping genes. Only three polymorphic sites were found and the isolates fell into four sequence types. These results show that S. typhi is a recent clone whose last common ancestor existed so recently that multiple mutations have not yet accumulated. Based on molecular clock rates for the accumulation of synonymous polymorphisms, we estimate that the last common ancestor of S. typhi existed 15,000-150,000 years ago, during the human hunter-gatherer phase and prior to the development of agriculture and the domestication of animals.

MeSH Terms

Evolution, Molecular Genes, Bacterial Genetics, Population Humans Molecular Sequence Data Polymorphism, Genetic Salmonella typhi/genetics Time Factors Typhoid Fever/microbiology

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Kidgell Claire

Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, The Flowers Building, Exhibition Road, South Kensington, London SW7 2AY, UK.

Reichard Ulrike

Wain John

Linz Bodo

Torpdahl Mia

Dougan Gordon

Achtman Mark

Article Info

Journal

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Abbr.

Infect Genet Evol

ISSN

1567-1348

DOI

10.1016/s1567-1348(02)00089-8

Published

2002-10-00

Pages

39-45

Language

English

Region

Netherlands

NLM ID

101084138

Subset

Databases

GENBANK

AY142218, AY142219, AY142220, AY142221, AY142222, AY142223, AY142224, AY142225, AY142226, AY142227, AY142228, AY142229, AY142230, AY142231, AY142232, AY142233, AY142234, AY142235, AY142236, AY142237, AY142238, AY142239, AY142240, AY142241

External Links

PubMed source DOI: 10.1016/s1567-1348(02)00089-8 View journal details

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Salmonella typhi, the causative agent of typhoid fever, is approximately 50,000 years old.

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