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PMID: 21247878 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of human miRNA precursors that resemble box C/D snoRNAs.

Nucleic acids research ·Vol. 39 ·No. 9 ·2011-05-00 ·Pages 3879-91

Ono M, Scott MS, Yamada K, Avolio F, Barton GJ, Lamond AI

Abstract

There are two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-specific modification of rRNA precursors and other nucleolar RNA targets. A previous computational and biochemical analysis revealed a possible evolutionary relationship between miRNA precursors and some box H/ACA snoRNAs. Here, we investigate a similar evolutionary relationship between a subset of miRNA precursors and box C/D snoRNAs. Computational analyses identified 84 intronic miRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D snoRNAs. Predictions of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity in the folded molecule. All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional box C/D snoRNP complexes. The data suggest that a subset of small regulatory RNAs may have evolved from box C/D snoRNAs.

MeSH Terms
Base Sequence Cell Nucleolus/genetics Chromosomal Proteins, Non-Histone/metabolism Humans MicroRNAs/analysis,chemistry,metabolism Molecular Sequence Data RNA Precursors/analysis,chemistry,metabolism RNA, Small Nucleolar/chemistry,metabolism
Chemicals
Chromosomal Proteins, Non-Histone MicroRNAs RNA Precursors RNA, Small Nucleolar fibrillarin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ono Motoharu
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Scott Michelle S
Yamada Kayo
Avolio Fabio
Barton Geoffrey J
Lamond Angus I
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkq1355
Published
2011-05-00
Epub
2011-00-18
Pages
3879-91
Language
English
Region
England
NLM ID
0411011
PMCID
PMC3089480
Subset
IM
Grants
Wellcome Trust · 097945 · United Kingdom
Wellcome Trust · 073980 · United Kingdom
Wellcome Trust · 083524 · United Kingdom
Wellcome Trust · WT083481 · United Kingdom
Wellcome Trust · 081361 · United Kingdom
Biotechnology and Biological Sciences Research Council · C12944 · United Kingdom
Medical Research Council · G0301131 · United Kingdom
Wellcome Trust · 037538 · United Kingdom
Wellcome Trust · 073980/Z/03/Z · United Kingdom
Medical Research Council · G0801738 · United Kingdom
Biotechnology and Biological Sciences Research Council · C08577 · United Kingdom
External Links
PubMed source DOI: 10.1093/nar/gkq1355 PMC Full Text View journal details
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