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PMID: 20596726 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production.

Molecular genetics and genomics : MGG ·Vol. 284 ·No. 2 ·2010-08-00 ·Pages 95-103

Miyoshi K, Miyoshi T, Siomi H

Abstract

MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that collectively regulate the expression of a large number of mRNAs by either promoting destabilization or repressing translation, or both. Therefore, they play a major role in shaping the transcriptomes and proteomes of eukaryotic organisms. Typically, animal miRNAs are produced from long primary transcripts with one or more of hairpin structures by two sequential processing reactions: one by Drosha in the nucleus and the other by Dicer in the cytoplasm. However, deviations from this paradigm have been observed: subclasses of miRNAs, which only partially meet the classical definition of a miRNA, are derived by alternative biogenesis pathways, thereby providing an additional level of complexity to miRNA-dependent regulation of gene expression.

MeSH Terms
Animals Cell Nucleus/genetics,metabolism DEAD-box RNA Helicases Eukaryota Gene Expression Regulation MicroRNAs/genetics,metabolism,physiology RNA, Messenger/genetics RNA, Untranslated/genetics Ribonuclease III/genetics,metabolism
Chemicals
MicroRNAs RNA, Messenger RNA, Untranslated DICER1 protein, human Ribonuclease III DEAD-box RNA Helicases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miyoshi Keita
Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. mkeita@a3.keio.jp
Miyoshi Tomohiro
Siomi Haruhiko
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Article Info
Journal
Molecular genetics and genomics : MGG
Abbr.
Mol Genet Genomics
ISSN
1617-4623
DOI
10.1007/s00438-010-0556-1
Email
mkeita@a3.keio.jp
Published
2010-08-00
Epub
2010-00-02
Pages
95-103
Language
English
Region
Germany
NLM ID
101093320
Subset
IM
External Links
PubMed source DOI: 10.1007/s00438-010-0556-1 View journal details
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