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PMID: 21189477 Published · ppublish English Research Support, Non-U.S. Gov't Review

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms.

Nature reviews. Microbiology ·Vol. 9 ·No. 2 ·2011-00-00 ·Pages 131-7

Medema MH, Breitling R, Bovenberg R, Takano E

Abstract

One of the most promising applications of synthetic biology is the biosynthesis of new drugs from secondary metabolites. Here, we survey a wide range of strategies that control the activity of biosynthetic modules in the cell in space and time, and illustrate how these strategies can be used to design efficient cellular synthetic production systems. Re-engineered versions of secondary metabolite biosynthetic pathways identified from any genomic sequence can then be inserted into these systems in a plug-and-play fashion.

MeSH Terms
Bacteria/genetics,metabolism Drug Discovery/methods,trends Gene Expression Regulation, Bacterial Synthetic Biology/methods,trends
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Medema Marnix H
Department of Microbial Physiology and the Groningen Bioinformatics Centre, University of Groningen, Nijenborgh 7, 9747AG Groningen, The Netherlands.
Breitling Rainer
Bovenberg Roel
Takano Eriko
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro2478
Published
2011-00-00
Epub
2010-00-29
Pages
131-7
Language
English
Region
England
NLM ID
101190261
Subset
IM
External Links
PubMed source DOI: 10.1038/nrmicro2478 View journal details
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