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PMID: 2113176 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of the serum-responsive transcription initiation site of the zinc finger gene Krox-20.

Molecular and cellular biology ·Vol. 10 ·No. 7 ·1990-07-00 ·Pages 3788-91

Cortner J, Farnham PJ

Abstract

The Krox-20 gene is rapidly and transiently induced when quiescent 3T3 cells are stimulated to reenter the proliferative cycle. We identified the major serum-responsive transcription initiation site and found that it differs from the initiation sites previously identified for the Krox-20 gene. Transcripts from the major serum-responsive initiation site increased at least 40-fold in serum-stimulated cells compared with logarithmically growing cells.

MeSH Terms
Animals Base Sequence Blood Cells, Cultured Culture Media Cycloheximide/pharmacology DNA-Binding Proteins/genetics Early Growth Response Protein 2 Gene Expression Regulation Genes Kinetics Metalloproteins/genetics Mice Molecular Sequence Data Nucleotide Mapping RNA, Messenger/genetics Sequence Homology, Nucleic Acid Transcription Factors/genetics Transcription, Genetic/drug effects
Chemicals
Culture Media DNA-Binding Proteins Early Growth Response Protein 2 Egr2 protein, mouse Metalloproteins RNA, Messenger Transcription Factors Cycloheximide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cortner J
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Farnham P J
References (18)
18 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.10.7.3788-3791.1990
Published
1990-07-00
Pages
3788-91
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC360834
Subset
IM
Grants
NCI NIH HHS · CA07175 · United States
NCI NIH HHS · CA09135 · United States
NCI NIH HHS · CA23076 · United States
External Links
PubMed source DOI: 10.1128/mcb.10.7.3788-3791.1990 PMC Full Text View journal details
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