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PMID: 21095156 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Genome mining for ribosomally synthesized natural products.

Current opinion in chemical biology ·Vol. 15 ·No. 1 ·2011-02-00 ·Pages 11-21

Velásquez JE, van der Donk WA

Abstract

In recent years, the number of known peptide natural products that are synthesized via the ribosomal pathway has rapidly grown. Taking advantage of sequence homology among genes encoding precursor peptides or biosynthetic proteins, in silico mining of genomes combined with molecular biology approaches has guided the discovery of a large number of new ribosomal natural products, including lantipeptides, cyanobactins, linear thiazole/oxazole-containing peptides, microviridins, lasso peptides, amatoxins, cyclotides, and conopeptides. In this review, we describe the strategies used for the identification of these ribosomally synthesized and posttranslationally modified peptides (RiPPs) and the structures of newly identified compounds. The increasing number of chemical entities and their remarkable structural and functional diversity may lead to novel pharmaceutical applications.

MeSH Terms
Biological Products/biosynthesis,chemistry,genetics Genome Mycotoxins/biosynthesis,chemistry,genetics Peptides/chemistry,genetics,metabolism Protein Processing, Post-Translational Ribosomes/metabolism
Chemicals
Biological Products Mycotoxins Peptides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Velásquez Juan E
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
van der Donk Wilfred A
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Article Info
Journal
Current opinion in chemical biology
Abbr.
Curr Opin Chem Biol
ISSN
1879-0402
DOI
10.1016/j.cbpa.2010.10.027
Published
2011-02-00
Epub
2010-00-20
Pages
11-21
Language
English
Region
England
NLM ID
9811312
PMCID
PMC3090663
Subset
IM
Grants
NIGMS NIH HHS · R01 GM058822 · United States
NIGMS NIH HHS · R01 GM058822-11 · United States
NIGMS NIH HHS · T32 GM070421 · United States
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1016/j.cbpa.2010.10.027 PMC Full Text View journal details
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