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PMID: 19642421 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.

Natural product reports ·Vol. 26 ·No. 4 ·2009-04-00 ·Pages 537-59

McIntosh JA, Donia MS, Schmidt EW

Abstract

Ribosomally synthesized bacterial natural products rival the nonribosomal peptides in their structural and functional diversity. The last decade has seen substantial progress in the identification and characterization of biosynthetic pathways leading to ribosomal peptide natural products with new and unusual structural motifs. In some of these cases, the motifs are similar to those found in nonribosomal peptides, and many are constructed by convergent or even paralogous enzymes. Here, we summarize the major structural and biosynthetic categories of ribosomally synthesized bacterial natural products and, where applicable, compare them to their homologs from nonribosomal biosynthesis.

MeSH Terms
Biological Products/biosynthesis,chemistry Molecular Structure Ribosomal Proteins/biosynthesis,chemistry Ribosomes/metabolism
Chemicals
Biological Products Ribosomal Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McIntosh John A
Department of Medicinal Chemistry, University of Utah, 30 South 2000 East Rm 201, Salt Lake City, UT 84112, USA.
Donia Mohamed S
Schmidt Eric W
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Article Info
Journal
Natural product reports
Abbr.
Nat Prod Rep
ISSN
0265-0568
DOI
10.1039/b714132g
Published
2009-04-00
Pages
537-59
Language
English
Region
England
NLM ID
8502408
PMCID
PMC2975598
Subset
IM
Grants
NIGMS NIH HHS · R01 GM071425 · United States
NIGMS NIH HHS · R01 GM071425-03 · United States
NIGMS NIH HHS · R01 GM071425-04 · United States
NIGMS NIH HHS · GM 071425 · United States
External Links
PubMed source DOI: 10.1039/b714132g PMC Full Text View journal details
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