FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.

3T3 Cells/drug effects Adenocarcinoma/drug therapy Animals Anti-Bacterial Agents/biosynthesis,chemistry,isolation & purification,pharmacology Antibiotics, Antineoplastic/chemistry,isolation & purification,pharmacology Carcinoma/drug therapy Cell Line, Transformed Chromobacterium/metabolism Depsipeptides Drug Screening Assays, Antitumor Female Fermentation Humans Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Nude Microbial Sensitivity Tests Neoplasm Transplantation Peptides, Cyclic Tacrolimus/pharmacology Tumor Cells, Cultured

Anti-Bacterial Agents Antibiotics, Antineoplastic Depsipeptides Peptides, Cyclic romidepsin Tacrolimus