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PMID: 21094035 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Chaperone-mediated autophagy in protein quality control.

Current opinion in cell biology ·Vol. 23 ·No. 2 ·2011-04-00 ·Pages 184-9

Arias E, Cuervo AM

Abstract

Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with compromised CMA have unveiled the important contribution of this pathway to protein quality control. In fact, CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.

MeSH Terms
Animals Autophagy Humans Lysosomes/metabolism Molecular Chaperones/metabolism Proteins/metabolism
Chemicals
Molecular Chaperones Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Arias Esperanza
Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cuervo Ana Maria
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2010.10.009
Published
2011-04-00
Epub
2010-00-18
Pages
184-9
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3078170
Subset
IM
Grants
NIDDK NIH HHS · P01 DK041918-20 · United States
NINDS NIH HHS · P50 NS038370 · United States
NINDS NIH HHS · NS038370 · United States
NIDDK NIH HHS · P01 DK041918 · United States
NIA NIH HHS · AG031782 · United States
NIA NIH HHS · R37 AG021904 · United States
NIA NIH HHS · R01 AG021904-09 · United States
NIA NIH HHS · P01 AG031782-03 · United States
NIA NIH HHS · R01 AG021904 · United States
NIDDK NIH HHS · DK041918 · United States
NIA NIH HHS · P01 AG031782 · United States
NIA NIH HHS · AG021904 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2010.10.009 PMC Full Text View journal details
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