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PMID: 18305538 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Autophagy fights disease through cellular self-digestion.

Nature ·Vol. 451 ·No. 7182 ·2008-02-28 ·Pages 1069-75

Mizushima N, Levine B, Cuervo AM, Klionsky DJ

Abstract

Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

MeSH Terms
Aging/physiology Animals Autophagy/immunology,physiology Cell Death Cell Survival Humans Immunity, Innate/immunology Neoplasms/pathology Neurodegenerative Diseases/pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mizushima Noboru
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Levine Beth
Cuervo Ana Maria
Klionsky Daniel J
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature06639
Published
2008-02-28
Pages
1069-75
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2670399
Subset
IM
Grants
NIA NIH HHS · R01 AG021904-06 · United States
NIA NIH HHS · R01 AG021904 · United States
NIA NIH HHS · R03 AG019834-02 · United States
NIA NIH HHS · R21 AG025355-02 · United States
NIA NIH HHS · R21 AG025355 · United States
External Links
PubMed source DOI: 10.1038/nature06639 PMC Full Text View journal details
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